A Russell Tupling
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Explore the profile of A Russell Tupling including associated specialties, affiliations and a list of published articles.
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73
Citations
1313
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Recent Articles
1.
Rahman F, Graham M, Adam A, Juracic E, Tupling A, Quadrilatero J
J Biomed Sci
. 2025 Feb;
32(1):29.
PMID: 39979946
Background: Skeletal muscle atrophy involves significant remodeling of fibers and is characterized by deficits in mitochondrial content and function. These changes are intimately connected to shifts in mitochondrial turnover, encompassing...
2.
Chang J, Thompson B, Doherty C, Mann L, Berdeklis A, Foster G, et al.
J Appl Physiol (1985)
. 2024 Oct;
137(6):1566-1579.
PMID: 39480272
Acute mountain sickness (AMS) occurs due to rapid altitude ascents and/or insufficient acclimatization. Acetazolamide (AZ) is commonly prescribed for AMS prophylaxis but inhibits exercise performance. Methazolamide (MZ), an analogous drug,...
3.
Wang D, Townsend L, DesOrmeaux G, Frangos S, Batchuluun B, Dumont L, et al.
Nature
. 2023 Jun;
619(7968):143-150.
PMID: 37380764
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its effectiveness, in...
4.
Marcadet L, Juracic E, Khan N, Bouredji Z, Yagita H, Ward L, et al.
Cells
. 2023 Jun;
12(11).
PMID: 37296659
Cardiomyopathy has become one of the leading causes of death in patients with Duchenne muscular dystrophy (DMD). We recently reported that the inhibition of the interaction between the receptor activator...
5.
Valentim M, Brahmbhatt A, Tupling A
Biosci Rep
. 2022 Nov;
42(12).
PMID: 36413081
In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation-contraction (E-C) coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of resting values. The sizable...
6.
Chambers P, Juracic E, Fajardo V, Tupling A
Am J Physiol Cell Physiol
. 2022 Jan;
322(3):C382-C394.
PMID: 35044855
Sarcolipin (SLN) is a small regulatory protein that inhibits the sarco(endo)plasmic reticulum Ca-ATPase (SERCA) pump. When bound to SERCA, SLN reduces the apparent Ca affinity of SERCA and uncouples SERCA...
7.
Hoang M, Jentz E, Janssen S, Nasteska D, Cuozzo F, Hodson D, et al.
Endocrinology
. 2021 Oct;
163(1).
PMID: 34718519
Pancreatic β-cells can secrete insulin via 2 pathways characterized as KATP channel -dependent and -independent. The KATP channel-independent pathway is characterized by a rise in several potential metabolic signaling molecules,...
8.
Fu M, Bombardier E, Gamu D, Tupling A
Biochem J
. 2020 Oct;
477(21):4281-4294.
PMID: 33111944
Na+-K+-ATPase from mice lacking the γ subunit exhibits decreased thermal stability. Phospholamban (PLN) and sarcolipin (SLN) are small homologous proteins that regulate sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) with properties similar to...
9.
Kirsh A, Juracic E, Petrick H, Monaco C, Barbeau P, Tupling A, et al.
Appl Physiol Nutr Metab
. 2020 May;
45(9):1049-1053.
PMID: 32379978
Dietary nitrate has been shown to increase cytosolic calcium concentrations within the heart, which would necessitate greater calcium sequestration for relaxation. In the present study we demonstrate that while nitrate...
10.
Hoang M, Paglialunga S, Bombardier E, Tupling A, Joseph J
Endocrinology
. 2019 Oct;
160(12):2825-2836.
PMID: 31580427
The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT)/hypoxia-inducible factor (HIF)-1β (ARNT/HIF1β) plays a key role in maintaining β-cell function and has been shown to be one of the most...