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Val A Fajardo

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Articles 67
Citations 619
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Recent Articles
1.
Copeland E, LeBlanc P, Duarte-Guterman P, Fajardo V, MacPherson R
J Physiol . 2025 Feb; PMID: 39937973
Age-related diseases are becoming more prominent as the lifespan of the global population rises. Many of these diseases coincide with each other and can even influence the onset of additional...
2.
Marais A, Baranowski R, Braun J, Hockey B, Fajardo V
Biochim Biophys Acta Mol Basis Dis . 2025 Jan; 1871(3):167694. PMID: 39864669
No abstract available.
3.
Brown A, Marko A, Marko D, Baranowski B, Silvera S, Finch M, et al.
FASEB J . 2025 Jan; 39(2):e70321. PMID: 39853792
This study, in vivo and in vitro, investigated the role of brain-derived neurotrophic factor (BDNF) in skeletal muscle adaptations to aerobic exercise. BDNF is a contraction-induced protein that may play...
4.
Kalailingam P, Ngan S, Iyappan R, Nehchiri A, Mohd-Kahliab K, Lee B, et al.
Aging Cell . 2025 Jan; :e14425. PMID: 39757428
Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable,...
5.
Marcella B, Hockey B, Braun J, Whitley K, Geromella M, Baranowski R, et al.
Nat Commun . 2024 Nov; 15(1):10210. PMID: 39587049
Inhibiting glycogen synthase kinase 3 (GSK3) improves muscle function, metabolism, and bone health in many diseases and conditions; however, whether GSK3 should be targeted for Duchenne muscular dystrophy (DMD), a...
6.
Gazzellone G, Lanteigne S, Gammage K, Fajardo V, Ditor D
Am J Lifestyle Med . 2024 Nov; :15598276231215271. PMID: 39554960
Research has shown that an anti-inflammatory diet can reduce inflammation and improve health outcomes in individuals with neurological disability, however, long term adherence is challenging. This study aimed to determine...
7.
Raun S, Braun J, Karavaeva I, Henriquez-Olguin C, Ali M, Moller L, et al.
Endocrinology . 2024 Aug; 165(10). PMID: 39136248
Context: Housing temperature is a critical regulator of mouse metabolism and thermoneutral housing can improve model translation to humans. However, the impact of housing temperature on the ability of wheel...
8.
Braun J, Fajardo V
NPJ Microgravity . 2024 Jul; 10(1):78. PMID: 39030182
Spending time in a microgravity environment is known to cause significant skeletal muscle atrophy and weakness via muscle unloading, which can be partly attributed to Ca dysregulation. The sarco(endo)plasmic reticulum...
9.
Barry C, Rouhana S, Braun J, Geromella M, Fajardo V, Pyle W
Biomolecules . 2024 Jun; 14(6). PMID: 38927078
Risk of cardiovascular disease mortality rises in women after menopause. While increased cardiovascular risk is largely attributed to postmenopausal declines in estrogens, the molecular changes in the heart that contribute...
10.
Nadile M, Sze N, Fajardo V, Tsiani E
Nutrients . 2024 May; 16(9). PMID: 38732504
Prostate cancer, accounting for 375,304 deaths in 2020, is the second most prevalent cancer in men worldwide. While many treatments exist for prostate cancer, novel therapeutic agents with higher efficacy...