V Krchnak
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Explore the profile of V Krchnak including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Ni Y, Krchnak V, Lebl M
Mol Divers
. 2002 Aug;
5(3):153-61.
PMID: 12197072
In an attempt to prepare 7-substituted 3,4-dihydroisoquinolinone family of compounds, we observed an unexpected decarboxylation. The reaction of 4-nitrohomophthalic anhydride with a Schiff base formed on solid support leads to...
2.
Krchnak V
Biotechnol Bioeng
. 1999 Jul;
61(3):135-41.
PMID: 10397801
A semi-automated technique for massive parallel solid-phase organic synthesis based on a "split only" strategy is described. Two different types of purpose-oriented reaction vessels are used. The initial steps are...
3.
Thorpe D, Yeoman H, Chan A, Krchnak V, Lebl M, Felder S
Biochem Biophys Res Commun
. 1999 Mar;
256(3):537-41.
PMID: 10080933
Among cell adhesion molecules, the classic Arg-Gly-Asp (RGD) motif is the best studied. We used combinatorial chemical and affinity immunochemical methods to find a novel motif of unnatural peptide ligands...
4.
Krchnak V, Padera V
Bioorg Med Chem Lett
. 1999 Jan;
8(22):3261-4.
PMID: 9873714
The domino block is a reaction block for manual and semi-automatic parallel solid-phase organic synthesis that simplifies liquid exchange and integrates common synthetic steps. The domino block consists of enclosed...
5.
6.
Salmon S, Zhao Y, Lebl M, Krchnak V, WERTMAN K, Sepetov N, et al.
Mol Divers
. 1996 Oct;
2(1-2):57-63.
PMID: 9238634
A single-step cancer cell cytotoxic assay system for anticancer drug discovery has been developed which facilitates rapid screening of large combinatorial chemical libraries synthesized using the 'one-bead-one-compound' (OBOC) methodology. Each...
7.
Vagner J, Barany G, Lam K, Krchnak V, Sepetov N, Ostrem J, et al.
Proc Natl Acad Sci U S A
. 1996 Aug;
93(16):8194-9.
PMID: 8710846
Proteolysis of short N alpha-protected peptide substrates bound to polyoxyethylene-polystyrene beads releases selectively free amino sites in the enzyme-accessible "surface" area. The substantial majority of functional sites in the "interior"...
8.
Krchnak V, Lebl M
Mol Divers
. 1996 May;
1(3):193-216.
PMID: 9237211
Various aspects of synthetic diversity generation and screening are discussed. Controversial issues are raised and different points of view are presented. We hope the article will stimulate thinking about the...
9.
Krchnak V, Weichsel A, Issakova O, Lam K, Lebl M
Mol Divers
. 1996 May;
1(3):177-82.
PMID: 9237208
A small-molecule synthetic combinatorial library was designed and synthesized that features potential pharmacophores attached to a variety of small cyclic scaffolds. The synthesis of the library involved randomization of three...
10.
Krchnak V, Weichsel A, Cabel D, Flegelova Z, Lebl M
Mol Divers
. 1996 May;
1(3):149-64.
PMID: 9237206
We have designed and synthesized structurally homogeneous and heterogeneous nonpeptide libraries. Structurally homogeneous libraries are characterized by the presence of one common structural unit, a scaffold, in all library compounds...