» Articles » PMID: 9237211

Synthetic Library Techniques: Subjective (biased and Generic) Thoughts and Views

Overview
Journal Mol Divers
Date 1996 May 1
PMID 9237211
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

Various aspects of synthetic diversity generation and screening are discussed. Controversial issues are raised and different points of view are presented. We hope the article will stimulate thinking about the utilization of library techniques and start a discussion about questions concerning their application.

Citing Articles

Limitations of the coupling of amino acid mixtures for the preparation of equimolar peptide libraries.

Boutin J, Gesson I, Henlin J, Bertin S, Lambert P, Volland J Mol Divers. 1997; 3(1):43-60.

PMID: 9527476 DOI: 10.1023/a:1009602707067.


Selection of a histidine-containing inhibitor of gelatinases through deconvolution of combinatorial tetrapeptide libraries.

Ferry G, Boutin J, Atassi G, Fauchere J, Tucker G Mol Divers. 1997; 2(3):135-46.

PMID: 9238644 DOI: 10.1007/BF01682201.

References
1.
Ohlmeyer M, SWANSON R, Dillard L, Reader J, Asouline G, Kobayashi R . Complex synthetic chemical libraries indexed with molecular tags. Proc Natl Acad Sci U S A. 1993; 90(23):10922-6. PMC: 47893. DOI: 10.1073/pnas.90.23.10922. View

2.
Scott J . Discovering peptide ligands using epitope libraries. Trends Biochem Sci. 1992; 17(7):241-5. DOI: 10.1016/0968-0004(92)90401-t. View

3.
Zuckermann R, Martin E, Spellmeyer D, Stauber G, Shoemaker K, Kerr J . Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library. J Med Chem. 1994; 37(17):2678-85. DOI: 10.1021/jm00043a007. View

4.
Lam K, Salmon S, Hersh E, Hruby V, Kazmierski W, Knapp R . A new type of synthetic peptide library for identifying ligand-binding activity. Nature. 1991; 354(6348):82-4. DOI: 10.1038/354082a0. View

5.
Lebl M, Patek M, Kocis P, Krchnak V, Hruby V, Salmon S . Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage-cleavage chemistry. Int J Pept Protein Res. 1993; 41(2):201-3. DOI: 10.1111/j.1399-3011.1993.tb00132.x. View