New Approach for Preparation of 2,3,7-trisubstituted 3,4-dihydroisoquinolinone Libraries on Solid Phase

Overview

Journal Mol Divers

Date 2002 Aug 29

PMID 12197072

Authors

Y Ni

V Krchnak

M Lebl

Affiliations

Soon will be listed here.

Abstract

In an attempt to prepare 7-substituted 3,4-dihydroisoquinolinone family of compounds, we observed an unexpected decarboxylation. The reaction of 4-nitrohomophthalic anhydride with a Schiff base formed on solid support leads to the formation of core structure. LC-MS and 1H NMR analysis confirmed the structure of unexpected intermediate. A library of 38,400 compounds was produced using this new synthetic approach.

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