Umut H Toprak
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Explore the profile of Umut H Toprak including associated specialties, affiliations and a list of published articles.
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29
Citations
1548
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Recent Articles
11.
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma
Jansky S, Sharma A, Korber V, Quintero A, Toprak U, Wecht E, et al.
Nat Genet
. 2021 Mar;
53(5):683-693.
PMID: 33767450
Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the single-cell transcriptomes of neuroblastomas...
12.
Afanasyeva E, Gartlgruber M, Ryl T, Decaesteker B, Denecker G, Monke G, et al.
Life Sci Alliance
. 2021 Mar;
4(5).
PMID: 33658318
The migrational propensity of neuroblastoma is affected by cell identity, but the mechanisms behind the divergence remain unknown. Using RNAi and time-lapse imaging, we show that ADRN-type NB cells exhibit...
13.
Hartlieb S, Sieverling L, Nadler-Holly M, Ziehm M, Toprak U, Herrmann C, et al.
Nat Commun
. 2021 Feb;
12(1):1269.
PMID: 33627664
Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas...
14.
Uhrig S, Ellermann J, Walther T, Burkhardt P, Frohlich M, Hutter B, et al.
Genome Res
. 2021 Jan;
31(3):448-460.
PMID: 33441414
The identification of gene fusions from RNA sequencing data is a routine task in cancer research and precision oncology. However, despite the availability of many computational tools, fusion detection remains...
15.
Lutsik P, Baude A, Mancarella D, Oz S, Kuhn A, Toth R, et al.
Nat Commun
. 2020 Oct;
11(1):5414.
PMID: 33110075
The neoplastic stromal cells of giant cell tumor of bone (GCTB) carry a mutation in H3F3A, leading to a mutant histone variant, H3.3-G34W, as a sole recurrent genetic alteration. We...
16.
George S, Lorenzi F, King D, Hartlieb S, Campbell J, Pemberton H, et al.
EBioMedicine
. 2020 Aug;
59:102971.
PMID: 32846370
Background: In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth...
17.
Patil P, Cieslak A, Bernhart S, Toprak U, Wagener R, Lopez C, et al.
Genes Chromosomes Cancer
. 2019 Nov;
59(4):261-267.
PMID: 31677197
T-cell prolymphocytic leukemia (T-PLL) is an aggressive tumor with leukemic presentation of mature T-lymphocytes. Here, we aimed at characterizing the initial events in the molecular pathogenesis of T-PLL and particularly,...
18.
Wagener R, Bens S, Toprak U, Seufert J, Lopez C, Scholz I, et al.
Haematologica
. 2019 May;
105(4):e202-e205.
PMID: 31073073
No abstract available.
19.
Paramasivam N, Hubschmann D, Toprak U, Ishaque N, Neidert M, Schrimpf D, et al.
Acta Neuropathol
. 2019 May;
138(2):295-308.
PMID: 31069492
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign 1-3, intermediate A and B, and malignant. Here, we set out...
20.
Lopez C, Kleinheinz K, Aukema S, Rohde M, Bernhart S, Hubschmann D, et al.
Nat Commun
. 2019 Mar;
10(1):1459.
PMID: 30926794
Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here,...