Umut H Toprak
Overview
Explore the profile of Umut H Toprak including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1548
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Recent Articles
1.
Weichenhan D, Riedel A, Sollier E, Toprak U, Hey J, Breuer K, et al.
Blood Adv
. 2024 Aug;
8(19):5100-5111.
PMID: 39121370
Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between break point partners (motor neuron and...
2.
Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking
Weichenhan D, Riedel A, Meinen C, Basic A, Toth R, Bahr M, et al.
Leukemia
. 2023 Mar;
37(5):1147-1150.
PMID: 36949154
No abstract available.
3.
Patil P, Toprak U, Seufert J, Braun T, Bernhart S, Wiehle L, et al.
Leuk Lymphoma
. 2022 Sep;
63(13):3253-3256.
PMID: 36083597
No abstract available.
4.
Radke J, Ishaque N, Koll R, Gu Z, Schumann E, Sieverling L, et al.
Nat Commun
. 2022 May;
13(1):2558.
PMID: 35538064
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of PCNSL have not been fully...
5.
Lopez C, Schleussner N, Bernhart S, Kleinheinz K, Sungalee S, Sczakiel H, et al.
Haematologica
. 2022 May;
108(2):543-554.
PMID: 35522148
Histone methylation-modifiers, such as EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated whole...
6.
Patil P, Hillebrecht S, Chteinberg E, Lopez C, Toprak U, Seufert J, et al.
Genes Chromosomes Cancer
. 2022 Feb;
61(7):432-436.
PMID: 35218115
Deregulation of micro(mi)-RNAs is a common mechanism in tumorigenesis. We investigated the expression of 2083 miRNAs in T-cell prolymphocytic leukemia (T-PLL). Compared to physiologic CD4+ and CD8+ T-cell subsets, 111...
7.
Gartlgruber M, Sharma A, Quintero A, Dreidax D, Jansky S, Park Y, et al.
Nat Cancer
. 2022 Feb;
2(1):114-128.
PMID: 35121888
Half of the children diagnosed with neuroblastoma (NB) have high-risk disease, disproportionately contributing to overall childhood cancer-related deaths. In addition to recurrent gene mutations, there is increasing evidence supporting the...
8.
Giesen N, Paramasivam N, Toprak U, Huebschmann D, Xu J, Uhrig S, et al.
Haematologica
. 2022 Jan;
107(8):1891-1901.
PMID: 35045690
The outcomes of patients with multiple myeloma (MM) refractory to immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs) remain poor. In this study, we performed whole genome and transcriptome sequencing of...
9.
Schmitt-Hoffner F, van Rijn S, Toprak U, Mauermann M, Rosemann F, Heit-Mondrzyk A, et al.
J Clin Oncol
. 2021 Jun;
39(29):3217-3228.
PMID: 34110923
Purpose: Clinical outcomes of patients with neuroblastoma range from spontaneous tumor regression to fatality. Hence, understanding the mechanisms that cause tumor progression is crucial for the treatment of patients. In...
10.
Hubschmann D, Kleinheinz K, Wagener R, Bernhart S, Lopez C, Toprak U, et al.
Leukemia
. 2021 May;
35(7):2002-2016.
PMID: 33953289
B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). Aberrant targeting of these mechanisms is implicated...