Umit Akbey
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Explore the profile of Umit Akbey including associated specialties, affiliations and a list of published articles.
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45
Citations
621
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Recent Articles
11.
Akbey U, Andreasen M
Chem Sci
. 2022 Jun;
13(22):6457-6477.
PMID: 35756505
Protein aggregation and amyloid formation have historically been linked with various diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids have gained a great deal of interest in...
12.
Akbey U
J Biomol NMR
. 2022 Jan;
76(1-2):23-28.
PMID: 34997409
Determination of protein structure and dynamics is key to understand the mechanism of protein action. Perdeuterated proteins have been used to obtain high resolution/sensitivty NMR experiments via proton-detection. These methods...
13.
Ferreira N, Gram H, Sorrentino Z, Gregersen E, Schmidt S, Reimer L, et al.
Acta Neuropathol
. 2021 May;
142(1):87-115.
PMID: 33978813
Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through the nervous system in a variety of neurodegenerative disorders including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy....
14.
Akbey U
J Magn Reson
. 2021 Apr;
327:106974.
PMID: 33823335
We describe a H based MAS nuclear magnetic resonance (NMR) method to obtain site-specific molecular dynamics of biomolecules. The method utilizes the use of deuterium nucleus as a spin label...
15.
Nagaraj M, Ahmed M, Lyngso J, Vad B, Boggild A, Fillipsen A, et al.
J Mol Biol
. 2020 Feb;
432(7):2232-2252.
PMID: 32084414
Protein fibrillation is traditionally associated with misfolding, loss of functional phenotype, and gain of toxicity in neurodegenerative diseases. However, many organisms exploit fibrils in the form of functional amyloids (FA),...
16.
Konig A, Scholzel D, Uluca B, Viennet T, Akbey U, Heise H
Solid State Nucl Magn Reson
. 2019 Jan;
98:1-11.
PMID: 30641444
In this article we give an overview over the use of DNP-enhanced solid-state NMR spectroscopy for the investigation of unfolded, disordered and misfolded proteins. We first provide an overview over...
17.
Jorgensen M, Lee Y, Bjerring M, Jepsen L, Akbey U, Cho Y, et al.
Dalton Trans
. 2018 Nov;
47(46):16737-16746.
PMID: 30426999
The new compound Sr(BH4)2(NH3BH3)2 has been synthesized and characterized with in situ powder X-ray diffraction and fast (28 or 60 kHz) magic angle spinning 1H, 11B and 15N NMR and...
18.
Diehl A, Roske Y, Ball L, Chowdhury A, Hiller M, Moliere N, et al.
Proc Natl Acad Sci U S A
. 2018 Mar;
115(13):3237-3242.
PMID: 29531041
Microorganisms form surface-attached communities, termed biofilms, which can serve as protection against host immune reactions or antibiotics. biofilms contain TasA as major proteinaceous component in addition to exopolysaccharides. In stark...
19.
Muschiol S, Erlendsson S, Aschtgen M, Oliveira V, Schmieder P, de Lichtenberg C, et al.
J Biol Chem
. 2017 Jun;
292(34):14134-14146.
PMID: 28659339
Type IV pili are important virulence factors on the surface of many pathogenic bacteria and have been implicated in a wide range of diverse functions, including attachment, twitching motility, biofilm...
20.
Geiger M, Orwick-Rydmark M, Marker K, Franks W, Akhmetzyanov D, Stoppler D, et al.
Phys Chem Chem Phys
. 2016 Oct;
18(44):30696-30704.
PMID: 27791210
Dynamic nuclear polarization exploits electron spin polarization to boost signal-to-noise in magic-angle-spinning (MAS) NMR, creating new opportunities in materials science, structural biology, and metabolomics studies. Since protein NMR spectra recorded...