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Umit Akbey

Explore the profile of Umit Akbey including associated specialties, affiliations and a list of published articles. Areas
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Articles 45
Citations 621
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Recent Articles
1.
Byeon C, Kinney T, Saricayir H, Hansen K, Scott F, Scott F, et al.
Angew Chem Int Ed Engl . 2025 Jan; e202418146. PMID: 39777964
Bacterial biofilms are major contributors to persistent infections and antimicrobial resistance, posing significant challenges to treatment. However, obtaining high-resolution structural information on native bacterial biofilms has remained elusive due to...
2.
Byeon C, Kinney T, Saricayir H, Hansen K, Scott F, Srinivasa S, et al.
bioRxiv . 2024 Oct; PMID: 39386544
Bacterial biofilms cause persistent infections that are difficult to treat and contribute greatly to antimicrobial resistance. However, high-resolution structural information on native bacterial biofilms remain very limited. This limitation is...
3.
Byeon C, Hansen K, DePas W, Akbey U
Solid State Nucl Magn Reson . 2024 Sep; 134:101970. PMID: 39312837
We present a high-resolution magic-angle spinning (MAS) solid-state NMR (ssNMR) study to characterize nontuberculous mycobacteria (NTM). We studied two different NTM strains, Mycobacterium smegmatis, a model, non-pathogenic strain, and Mycobacterium...
4.
Hansen K, Byeon C, Liu Q, Drace T, Boesen T, Conway J, et al.
Proc Natl Acad Sci U S A . 2024 Aug; 121(33):e2406775121. PMID: 39116134
Biofilm-protected pathogenic causes chronic infections that are difficult to treat. An essential building block of these biofilms are functional amyloid fibrils that assemble from phenol-soluble modulins (PSMs). PSMα1 cross-seeds other...
5.
Byeon C, Hansen K, Jeffrey J, Saricayir H, Andreasen M, Akbey U
FEBS J . 2024 Feb; 291(9):1925-1943. PMID: 38349812
Functional bacterial amyloids play a crucial role in the formation of biofilms, which mediate chronic infections and contribute to antimicrobial resistance. This study focuses on the FapC amyloid fibrillar protein...
6.
Byeon C, Kinney T, Saricayir H, Srinivasa S, Wells M, Kim W, et al.
J Magn Reson . 2023 Nov; 357:107587. PMID: 37984030
We present a multidimensional magic-angle spinning (MAS) solid-state NMR (ssNMR) study to characterize native Pseudomonas fluorescens colony biofilms at natural abundance without isotope-labelling. By using a high-resolution INEPT-based 2D H-C...
7.
Byeon C, Kinney T, Saricayir H, Srinivasa S, Wells M, Kim W, et al.
bioRxiv . 2023 Oct; PMID: 37873242
We present a high-resolution 1D and 2D magic-angle spinning (MAS) solid-state NMR (ssNMR) study to characterize native colony biofilms at natural abundance without isotope-labelling. By using a high-resolution INEPT-based 2D...
8.
Byeon C, Akbey U
Biomol NMR Assign . 2023 Oct; 17(2):275-280. PMID: 37798606
FapA is an accessory protein within the biofilm forming functional bacterial amyloid related fap-operon in Pseudomonas, and maybe a chaperone for FapC controlling its fibrillization. To allow further structural analysis,...
9.
Byeon C, Wang P, Byeon I, Akbey U
Biomol NMR Assign . 2023 May; 17(2):159-165. PMID: 37162737
Functional bacterial amyloids provide structural scaffolding to bacterial biofilms. In contrast to the pathological amyloids, they have a role in vivo and are tightly regulated. Their presence is essential to...
10.
Akbey U
Solid State Nucl Magn Reson . 2023 Mar; 125:101861. PMID: 36989552
A novel deuterium-excited and proton-detected quadruple-resonance three-dimensional (3D) HcNH MAS nuclear magnetic resonance (NMR) method is presented to obtain site-specific H deuterium quadrupolar couplings from protein backbone, as an extension...