Umesh Varshney
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Explore the profile of Umesh Varshney including associated specialties, affiliations and a list of published articles.
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129
Citations
1141
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Recent Articles
11.
Kesharwani S, Raj P, Paul A, Roy K, Bhanot A, Mehta A, et al.
Eur J Med Chem
. 2023 Jul;
258:115604.
PMID: 37399710
Uracil DNA glycosylase (UDG or Ung) is a key enzyme involved in uracil excision from the DNA as a repair mechanism. Designing Ung inhibitors is thus a promising strategy to...
12.
Aroli S, Woo E, Gopal B, Varshney U
Nucleic Acids Res
. 2023 Jun;
51(13):6554-6565.
PMID: 37283083
UdgX excises uracil from uracil-containing DNA to concurrently form a covalent bond with the resulting AP-DNA. Structurally, UdgX is highly similar to family-4 UDGs (F4-UDGs). However, UdgX is unique in...
13.
Sah S, Varshney U
Microbiology (Reading)
. 2023 Feb;
169(2).
PMID: 36745551
Methionyl-tRNA formyltransferase (Fmt)-mediated formylation of Met-tRNA to fMet-tRNA is crucial for efficient initiation of translation in bacteria and the eukaryotic organelles. Folate dehydrogenase-cyclohydrolase (FolD), a bifunctional enzyme, carries out conversion...
14.
Naz S, Paritosh K, Sanyal P, Khan S, Singh Y, Varshney U, et al.
Elife
. 2023 Jan;
12.
PMID: 36695572
The emergence of drug resistance in () is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis using 2237 clinical strains of to identify novel genetic...
15.
Singh J, Mishra R, Ayyub S, Hussain T, Varshney U
Nucleic Acids Res
. 2022 Nov;
50(20):11712-11726.
PMID: 36399509
Initiation factor 3 (IF3) regulates the fidelity of bacterial translation initiation by debarring the use of non-canonical start codons or non-initiator tRNAs and prevents premature docking of the 50S ribosomal...
16.
Raj P, Selvam K, Roy K, Tripathi S, Kesharwani S, Gopal B, et al.
Bioorg Med Chem Lett
. 2022 Sep;
76:129008.
PMID: 36174837
Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng), a key DNA repair enzyme, represents an attractive target for the design of new antimycobacterial agents. However, only a limited number of weak MtUng inhibitors...
17.
Roy Chowdhury A, Sah S, Varshney U, Chakravortty D
PLoS Pathog
. 2022 Aug;
18(8):e1010708.
PMID: 35969640
Bacterial porins are highly conserved outer membrane proteins used in the selective transport of charged molecules across the membrane. In addition to their significant contributions to the pathogenesis of Gram-negative...
18.
Lahry K, Gopal A, Sahu A, Marbaniang C, Shah R, Mehta A, et al.
J Mol Biol
. 2022 Apr;
434(12):167588.
PMID: 35439479
The fidelity of initiator tRNA (i-tRNA) selection in the ribosomal P-site is a key step in translation initiation. The highly conserved three consecutive G:C base pairs (3GC pairs) in the...
19.
Kapoor I, Shaw A, Naha A, Emam E, Varshney U
DNA Repair (Amst)
. 2022 Mar;
113:103316.
PMID: 35306347
Cross-talks between DNA repair pathways are emerging as a crucial strategy in the maintenance of the genomic integrity. A double-stranded (ds) DNA specific DNA glycosylase, UdgB is known to excise...
20.
Datta M, Singh J, Modak M, Pillai M, Varshney U
Mol Microbiol
. 2021 Dec;
117(2):462-479.
PMID: 34889476
The anticodon stem of initiator tRNA (i-tRNA) possesses the characteristic three consecutive GC base pairs (G29:C41, G30:C40, and G31:C39 abbreviated as GC/GC/GC or 3GC pairs) crucial to commencing translation. To...