Umesh Varshney
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Explore the profile of Umesh Varshney including associated specialties, affiliations and a list of published articles.
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129
Citations
1141
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Recent Articles
1.
Emam E, Roy K, Singh D, Saini D, Varshney U
J Bacteriol
. 2024 Dec;
207(1):e0031424.
PMID: 39660902
MutT proteins are Nudix hydrolases characterized by the presence of a Nudix box, GX5EX7REUXEEXGU, where U is a bulky hydrophobic residue and X is any residue. Major MutT proteins hydrolyze...
2.
Singh J, Varshney U
IUBMB Life
. 2024 Nov;
77(1):e2927.
PMID: 39578968
Initiation factors play critical roles in fine-tuning translation initiation, which is the first and the rate-limiting step in protein synthesis. In bacteria, initiation factors, IF1, IF2 and IF3 work in...
3.
Sahu A, Shah R, Nashier D, Sharma P, Varada R, Lahry K, et al.
J Bacteriol
. 2024 Aug;
206(9):e0025124.
PMID: 39171914
Importance: harbors four initiator tRNA (i-tRNA) genes: three of these at and the fourth one at loci. In B, all four genes encode i-tRNA. In K, because of a single-nucleotide...
4.
Singh S, Singh J, Varshney U
J Bacteriol
. 2024 Jun;
206(7):e0011924.
PMID: 38837341
Importance: RsgA is a late-stage ribosome biogenesis factor. Earlier, (IF2) was isolated as a multicopy suppressor of the Δ strain. How IF2 rescued the strain growth remained unclear. This study...
5.
Emam E, Roy K, Varshney U
DNA Repair (Amst)
. 2024 May;
139:103693.
PMID: 38776712
MutT proteins belong to the Nudix hydrolase superfamily that includes a diverse group of Mg requiring enzymes. These proteins use a generalized substrate, nucleoside diphosphate linked to a chemical group...
6.
Singh J, Singh S, Emam E, Varshney U
Mitochondrion
. 2024 Apr;
76:101876.
PMID: 38599301
Ribosome biogenesis, involving processing/assembly of rRNAs and r-proteins is a vital process. In Saccharomyces cerevisiae mitochondria, ribosomal small subunit comprises 15S rRNA (15S). While the 15S 5'-end processing uses Ccm1p...
7.
Lahry K, Datta M, Varshney U
Mol Microbiol
. 2024 Feb;
122(5):772-788.
PMID: 38410838
Translation of messenger RNA (mRNA) in bacteria occurs in the steps of initiation, elongation, termination, and ribosome recycling. The initiation step comprises multiple stages and uses a special transfer RNA...
8.
Varshney U
J Biosci
. 2023 Nov;
48.
PMID: 38018541
The symbiotic evolution between the two prokaryotic domains of life (bacteria and archaea) is believed to have given rise to the third domain of life, the eukaryotes. Common to all...
9.
Potdar V, Vijay N, Mukhopadhyay L, Aggarwal N, Bhardwaj S, Choudhary M, et al.
Front Public Health
. 2023 Nov;
11:1218292.
PMID: 37927860
Background: Over time, COVID-19 testing has significantly declined across the world. However, it is critical to monitor the virus through surveillance. In late 2020, WHO released interim guidance advising the...
10.
Singh S, Lahry K, Mandava C, Singh J, Shah R, Sanyal S, et al.
RNA Biol
. 2023 Sep;
20(1):681-692.
PMID: 37676049
Lamotrigine (Ltg), an anticonvulsant drug, targets initiation factor 2 (IF2), compromises ribosome biogenesis and causes toxicity to . However, our understanding of Ltg toxicity in remains unclear. While our assays...