Twan van den Beucken
Overview
Explore the profile of Twan van den Beucken including associated specialties, affiliations and a list of published articles.
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40
Citations
1585
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Recent Articles
1.
Guo K, van den Beucken T
Cell Biosci
. 2024 Nov;
14(1):134.
PMID: 39488681
Drug-induced liver injury (DILI) refers to drug-mediated damage to the structure and function of the liver, ranging from mild elevation of liver enzymes to severe hepatic insufficiency, and in some...
2.
Lienhard M, van den Beucken T, Timmermann B, Hochradel M, Borno S, Caiment F, et al.
Bioinformatics
. 2023 Jun;
39(6).
PMID: 37267159
Motivation: Long-read transcriptome sequencing (LRTS) has the potential to enhance our understanding of alternative splicing and the complexity of this process requires the use of versatile computational tools, with the...
3.
Rupaimoole R, Wu S, Pradeep S, Ivan C, Pecot C, Gharpure K, et al.
Nat Commun
. 2020 Jun;
11(1):2867.
PMID: 32493919
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Smit E, Kleinjans J, van den Beucken T
Toxicol In Vitro
. 2018 Nov;
54:330-337.
PMID: 30385349
Cellular adaptation is important to cope with various stresses induced by altered environmental conditions. By controlling mRNA translation rates cells may adapt to stress to promote survival. Phosphorylation of eIF2α...
5.
Smit E, Caiment F, Piepers J, Kleinjans J, van den Beucken T
Toxicol Lett
. 2018 Jun;
295:144-152.
PMID: 29906497
Translational control is a cellular response mechanism which initiates adaptation during various stress situations. Here, we investigated the role of translational control after benzo[a]pyrene (BaP) exposure in primary mouse hepatocytes....
6.
Briede J, Deferme L, Wolters J, Claessen S, van den Beucken T, Wagner R, et al.
Toxicol In Vitro
. 2018 Feb;
48:318-328.
PMID: 29432895
Regulation of DNA methylation plays a crucial role in biological processes and carcinogenesis. The formation of 5-hydroxymethylcytosine (5hmC) by oxidation of 5-methylcytosine (5mC) has been proposed as an intermediate of...
7.
Smit E, Souza T, Jennen D, Kleinjans J, van den Beucken T
Toxicology
. 2017 Sep;
390:74-82.
PMID: 28882572
DNA damage mediates widespread changes in transcription through activation or repression of transcription factors (TFs). However, the consequences of regulating specific TFs for the outcome of the DNA repair process...
8.
Adriaens M, Prickaerts P, Chan-Seng-Yue M, van den Beucken T, Dahlmans V, Eijssen L, et al.
Epigenetics Chromatin
. 2016 Nov;
9:48.
PMID: 27822313
Background: A comprehensive assessment of the epigenetic dynamics in cancer cells is the key to understanding the molecular mechanisms underlying cancer and to improving cancer diagnostics, prognostics and treatment. By...
9.
Prickaerts P, Adriaens M, van den Beucken T, Koch E, Dubois L, Dahlmans V, et al.
Epigenetics Chromatin
. 2016 Nov;
9:46.
PMID: 27800026
Background: Trimethylation at histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3) controls gene activity during development and differentiation. Whether H3K4me3 and H3K27me3 changes dynamically in response to altered microenvironmental...
10.
Souza T, Rieswijk L, van den Beucken T, Kleinjans J, Jennen D
Toxicology
. 2016 Oct;
375:58-63.
PMID: 27765683
Chemical carcinogenesis, albeit complex, often relies on modulation of transcription through activation or repression of key transcription factors. While analyzing extensive networks may hinder the biological interpretation, one may focus...