Kasper M A Rouschop
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Explore the profile of Kasper M A Rouschop including associated specialties, affiliations and a list of published articles.
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53
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4896
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Recent Articles
1.
Barbeau L, Beelen N, Savelkouls K, Keulers T, Wieten L, Rouschop K
PLoS One
. 2025 Feb;
20(2):e0316716.
PMID: 39928678
In the last decade, advancements in understanding the genetic landscape of lung squamous cell carcinoma (LUSC) have significantly impacted therapy development. Immune checkpoint inhibitors (ICI) have shown great promise, improving...
2.
Sanchez-Castillo A, Savelkouls K, Baldini A, Hounjet J, Sonveaux P, Verstraete P, et al.
Oncogenesis
. 2024 Nov;
13(1):39.
PMID: 39537592
The serine/glycine (ser/gly) synthesis pathway branches from glycolysis and is hyperactivated in approximately 30% of cancers. In ~13% of glioblastoma cases, we observed frequent amplifications and rare mutations in the...
3.
Beaumont J, Barbeau L, Ju J, Savelkouls K, Bouwman F, Zonneveld M, et al.
J Extracell Vesicles
. 2024 Jul;
13(7):e12449.
PMID: 39001708
Hypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on cellular metabolism. As such, hypoxia is...
4.
Beaumont J, Ju J, Barbeau L, Demers I, Savelkouls K, Derks K, et al.
Radiother Oncol
. 2023 Oct;
190:109968.
PMID: 37898438
Background And Purpose: Hypoxia is a common feature of tumours, associated with poor prognosis due to increased resistance to radio- and chemotherapy and enhanced metastasis development. Previously we demonstrated that...
5.
Lempesis I, Hoebers N, Essers Y, Jocken J, Rouschop K, Blaak E, et al.
Cells
. 2022 Nov;
11(22).
PMID: 36428961
Adipose tissue (AT) inflammation may increase obesity-related cardiometabolic complications. Altered AT oxygen partial pressure (pO) may impact the adipocyte inflammatory phenotype. Here, we investigated the effects of pO levels on...
6.
Beaumont J, Beelen N, Wieten L, Rouschop K
Cancers (Basel)
. 2022 Aug;
14(16).
PMID: 36010994
Tumor-associated immune cells frequently display tumor-supportive phenotypes. These phenotypes, induced by the tumor microenvironment (TME), are described for both the adaptive and the innate arms of the immune system. Furthermore,...
7.
Vaes R, Reynders K, Sprooten J, Nevola K, Rouschop K, Vooijs M, et al.
Cancers (Basel)
. 2021 Dec;
13(24).
PMID: 34944879
Radiotherapy (RT) and chemotherapy can induce immune responses, but not much is known regarding treatment-induced immune changes in patients. This exploratory study aimed to identify potential prognostic and predictive immune-related...
8.
Keulers T, Koch A, van Gisbergen M, Barbeau L, Zonneveld M, de Jong M, et al.
Autophagy
. 2021 Dec;
18(8):1898-1914.
PMID: 34904929
Hypoxia is a common feature of solid tumors and is associated with increased tumor progression, resistance to therapy and increased metastasis. Hence, tumor hypoxia is a prognostic factor independent of...
9.
Keulers T, Libregts S, Beaumont J, Savelkouls K, Bussink J, Duimel H, et al.
J Extracell Vesicles
. 2021 Dec;
10(14):e12166.
PMID: 34859607
Tumour hypoxia is a hallmark of solid tumours and contributes to tumour progression, metastasis development and therapy resistance. In response to hypoxia, tumour cells secrete pro-angiogenic factors to induce blood...
10.
van Meijel R, Vogel M, Jocken J, Vliex L, Smeets J, Hoebers N, et al.
Mol Metab
. 2021 Jul;
53:101287.
PMID: 34224918
Objective: Recent studies suggest that hypoxia exposure may improve glucose homeostasis, but well-controlled human studies are lacking. We hypothesized that mild intermittent hypoxia (MIH) exposure decreases tissue oxygen partial pressure...