Tsuyoshi Osawa
Overview
Explore the profile of Tsuyoshi Osawa including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
978
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0
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Recent Articles
1.
Ikeda H, Kawase K, Nishi T, Watanabe T, Takenaga K, Inozume T, et al.
Nature
. 2025 Feb;
639(8053):E5.
PMID: 39948434
No abstract available.
2.
Ikeda H, Kawase K, Nishi T, Watanabe T, Takenaga K, Inozume T, et al.
Nature
. 2025 Jan;
638(8049):225-236.
PMID: 39843734
Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in...
3.
Katoh M, Nomura S, Yamada S, Ito M, Hayashi H, Katagiri M, et al.
Circulation
. 2024 Jul;
150(5):374-389.
PMID: 38991046
Background: The heart comprises many types of cells such as cardiomyocytes, endothelial cells (ECs), fibroblasts, smooth muscle cells, pericytes, and blood cells. Every cell type responds to various stressors (eg,...
4.
Amano H, Uchida H, Harada K, Narita A, Fumino S, Yamada Y, et al.
Cancer Sci
. 2024 Feb;
115(5):1634-1645.
PMID: 38411285
The urinary catecholamine metabolites, homovanillic acid (HVA) and vanillylmandelic acid (VMA), are used for the adjunctive diagnosis of neuroblastomas. We aimed to develop a scoring system for the diagnosis and...
5.
Kato M, Maeda K, Nakahara R, Hirose H, Kondo A, Aki S, et al.
PNAS Nexus
. 2023 Oct;
2(10):pgad306.
PMID: 37822765
An acidic tumor microenvironment plays a critical role in tumor progression. However, understanding of metabolic reprogramming of tumors in response to acidic extracellular pH has remained elusive. Using comprehensive metabolomic...
6.
Sakata J, Tatsumi T, Sugiyama A, Shimizu A, Inagaki Y, Katoh H, et al.
Protein Expr Purif
. 2023 Oct;
214:106375.
PMID: 37797818
Antibody-mimetic drug conjugate (AMDC) is a cancer cell-targeted drug delivery system based on the non-covalent binding of mutated streptavidin and modified biotin, namely Cupid and Psyche. However, the development of...
7.
Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, et al.
EMBO J
. 2023 Oct;
42(22):e114032.
PMID: 37781951
Bone marrow-derived cells (BMDCs) infiltrate hypoxic tumors at a pre-angiogenic state and differentiate into mature macrophages, thereby inducing pro-tumorigenic immunity. A critical factor regulating this differentiation is activation of SREBP2-a...
8.
Hibino S, Eto S, Hangai S, Endo K, Ashitani S, Sugaya M, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(24):e2305245120.
PMID: 37276392
The activation and expansion of T cells that recognize cancer cells is an essential aspect to antitumor immunity. Tumors may escape destruction by the immune system through ectopic expression of...
9.
Kitagawa A, Osawa T, Noda M, Kobayashi Y, Aki S, Nakano Y, et al.
Br J Cancer
. 2023 Apr;
128(12):2206-2217.
PMID: 37076565
Background: Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with multiple genomic aberrations makes them intractable. Therefore, the pathogenesis and metabolic changes of ICC...
10.
Hirose S, Waku T, Tani M, Masuda H, Endo K, Ashitani S, et al.
iScience
. 2023 Feb;
26(2):106045.
PMID: 36818298
Cancer cells coordinate the mTORC1 signals and the related metabolic pathways to robustly and rapidly grow in response to nutrient conditions. Although a CNC-family transcription factor NRF3 promotes cancer development,...