Tsuneyasu Kaisho
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Explore the profile of Tsuneyasu Kaisho including associated specialties, affiliations and a list of published articles.
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150
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13114
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Recent Articles
1.
Chua Y, Draper S, Le S, de Menezes M, Ganley M, Ge Z, et al.
Cell Rep
. 2025 Feb;
44(2):115295.
PMID: 39946236
We recently demonstrated that vaccines comprising antigenic peptides conjugated to a glycolipid agonist, termed glycolipid-peptide (GLP) vaccines, efficiently generate substantial numbers of long-lived CD8 liver-resident memory T (Trm) cells that...
2.
Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, et al.
J Exp Med
. 2025 Jan;
222(3).
PMID: 39853307
Lysosomal stress due to the accumulation of nucleic acids (NAs) activates endosomal TLRs in macrophages. Here, we show that lysosomal RNA stress, caused by the lack of RNase T2, induces...
3.
Suzuki S, Komiya K, Tsuda S, Yoshino M, Kaisho T, Bergsagel P, et al.
Front Immunol
. 2024 Oct;
15:1444821.
PMID: 39474418
Purpose: Type I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing immune tolerance for self-antigens and tumor antigens. However, it remains unclear...
4.
Kusumoto Y, Ueda M, Hashimoto M, Takeuchi H, Okada N, Yamamoto J, et al.
JCI Insight
. 2024 Oct;
9(21).
PMID: 39352752
The oral mucosa is the first line of defense against pathogenic bacteria and plays a vital role in maintaining tolerance to food antigens and commensal bacteria. We used CD11c reporter...
5.
Takaoka M, Zhao X, Lim H, Magnussen C, Ang O, Suffee N, et al.
Nature
. 2024 Sep;
634(8033):457-465.
PMID: 39231480
Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time...
6.
Mitchell J, Spanier J, Dwyer A, Knutson T, Alkhatib M, Qian G, et al.
Immunity
. 2024 Aug;
57(10):2399-2415.e8.
PMID: 39214091
T cell-mediated islet destruction is a hallmark of autoimmune diabetes. Here, we examined the dynamics and pathogenicity of CD4 T cell responses to four different insulin-derived epitopes during diabetes initiation...
7.
Sasaki I, Fukuda-Ohta Y, Nakai C, Wakaki-Nishiyama N, Okamoto C, Okuzaki D, et al.
Cell Rep
. 2024 Mar;
43(4):113981.
PMID: 38520688
Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a...
8.
Sasaki I, Kato T, Kanazawa N, Kaisho T
Adv Exp Med Biol
. 2024 Mar;
1444:83-95.
PMID: 38467974
The number of human inborn errors of immunity has now gone beyond 430. The responsible gene variants themselves are apparently the cause for the disorders, but the underlying molecular or...
9.
English K, Kwan R, Holz L, McGuffog C, Krol J, Kempe D, et al.
Nat Commun
. 2024 Feb;
15(1):1261.
PMID: 38341416
While CD4 T cells are a prerequisite for CD8 T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to intrahepatic CD8 T cells are unknown....
10.
Kumar S, Biswas M, Cao D, Arisa S, Munoz-Melero M, Lam A, et al.
Mol Ther
. 2023 Dec;
32(2):325-339.
PMID: 38053332
Upon viral infection of the liver, CD8 T cell responses may be triggered despite the immune suppressive properties that manifest in this organ. We sought to identify pathways that activate...