Tristan Vaughan
Overview
Explore the profile of Tristan Vaughan including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
300
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0
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Recent Articles
1.
Porebski B, Balmforth M, Browne G, Riley A, Jamali K, Furst M, et al.
Nat Biomed Eng
. 2023 Oct;
8(3):214-232.
PMID: 37814006
Developing therapeutic antibodies is laborious and costly. Here we report a method for antibody discovery that leverages the Illumina HiSeq platform to, within 3 days, screen in the order of...
2.
Murray T, Kozakowska-McDonnell K, Tibbles A, Taylor A, Higazi D, Rossy E, et al.
MAbs
. 2021 Nov;
13(1):1992068.
PMID: 34781832
Bioconjugates are an important class of therapeutic molecules. To date, glycan-based metabolic glycoengineering has had limited use in this field, due to the complexities of the endogenous glycosylation pathway and...
3.
Cox T, Gunther E, Brody A, Chiasseu M, Stoner A, Smith L, et al.
Ann Clin Transl Neurol
. 2019 Mar;
6(3):554-574.
PMID: 30911579
Objective: Amyloid-beta oligomers (Aßo) trigger the development of Alzheimer's disease (AD) pathophysiology. Cellular prion protein (PrPC) initiates synaptic damage as a high affinity receptor for Aßo. Here, we evaluated the...
4.
Chodorge M, Celeste A, Grimsby J, Konkar A, Davidsson P, Fairman D, et al.
Sci Rep
. 2018 Dec;
8(1):17545.
PMID: 30510163
Type 2 diabetes (T2D) is a complex and progressive disease requiring polypharmacy to manage hyperglycaemia and cardiovascular risk factors. However, most patients do not achieve combined treatment goals. To address...
5.
Spooner W, McLaren W, Slidel T, Finch D, Butler R, Campbell J, et al.
Nat Commun
. 2018 Oct;
9(1):4128.
PMID: 30297836
Selecting the most appropriate protein sequences is critical for precision drug design. Here we describe Haplosaurus, a bioinformatic tool for computation of protein haplotypes. Haplosaurus computes protein haplotypes from pre-existing...
6.
Longatti A, Schindler C, Collinson A, Jenkinson L, Matthews C, FitzPatrick L, et al.
Nanoscale
. 2018 Jul;
10(29):14230-14244.
PMID: 30010165
Exosomes are extracellular vesicles that mediate cell-to-cell communication by transferring biological cargo, such as DNA, RNA and proteins. Through genetic engineering of exosome-producing cells or manipulation of purified exosomes, it...
7.
Tigue N, Bamber L, Andrews J, Ireland S, Hair J, Carter E, et al.
Oncoimmunology
. 2017 Apr;
6(3):e1280645.
PMID: 28405505
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing...
8.
Popovic B, Gibson S, Senussi T, Carmen S, Kidd S, Slidel T, et al.
Protein Eng Des Sel
. 2017 Jan;
30(4):303-311.
PMID: 28130326
High levels of protein expression are key to the successful development and manufacture of a therapeutic antibody. Here, we describe two related antibodies, Ab001 and Ab008, where Ab001 shows a...
9.
Buchanan A, Newton P, Pehrsson S, Inghardt T, Antonsson T, Svensson P, et al.
Blood
. 2015 Mar;
125(22):3484-90.
PMID: 25788700
Ticagrelor is a direct-acting reversibly binding P2Y12 antagonist and is widely used as an antiplatelet therapy for the prevention of cardiovascular events in acute coronary syndrome patients. However, antiplatelet therapy...
10.
Spooner J, Keen J, Nayyar K, Birkett N, Bond N, Bannister D, et al.
Biotechnol Bioeng
. 2015 Jan;
112(7):1472-7.
PMID: 25619171
Fabs are an important class of antibody fragment as both research reagents and therapeutic agents. There are a plethora of methods described for their recombinant expression and purification. However, these...