Travis W Bainbridge
Overview
Explore the profile of Travis W Bainbridge including associated specialties, affiliations and a list of published articles.
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18
Citations
1070
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Recent Articles
1.
Qin D, Phung Q, Wu P, Yin Z, Tam S, Tran P, et al.
Front Immunol
. 2025 Feb;
16:1519452.
PMID: 40018031
Introduction: As a crucial asset for human health and modern medicine, an increasing number of biotherapeutics are entering the clinic. However, due to their complexity, these drugs have a higher...
2.
Hosseini I, Fleisher B, Getz J, Decalf J, Kwong M, Ovacik M, et al.
Pharmaceutics
. 2024 May;
16(5).
PMID: 38794321
FLT3L-Fc is a half-life extended, effectorless Fc-fusion of the native human FLT3-ligand. In cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic/pharmacodynamic (PK/PD) relationship, with observed nonlinear PK and...
3.
Wu K, Adedeji A, Zabka T, Hosseini I, Kenkre R, Getz J, et al.
Toxicol Appl Pharmacol
. 2024 Jan;
483:116837.
PMID: 38278496
FLT3L-Fc is a cytokine-Fc fusion agonizing receptor-type tyrosine-protein kinase FLT3 (fms-related tyrosine kinase 3; CD135). FLT3 is expressed on dendritic cells (DCs) as well as myeloid and lymphoid progenitors. Nonclinical...
4.
Cox C, Storm E, Kapoor V, Chavarria-Smith J, Lin D, Wang L, et al.
Sci Immunol
. 2021 May;
6(59).
PMID: 33963061
Repair of the intestinal epithelium is tightly regulated to maintain homeostasis. The response after epithelial damage needs to be local and proportional to the insult. How different types of damage...
5.
Meilandt W, Maloney J, Imperio J, Lalehzadeh G, Earr T, Crowell S, et al.
Alzheimers Res Ther
. 2019 Dec;
11(1):97.
PMID: 31787113
Background: Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer's disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab...
6.
Dominguez C, Muller S, Keerthivasan S, Koeppen H, Hung J, Gierke S, et al.
Cancer Discov
. 2019 Nov;
10(2):232-253.
PMID: 31699795
With only a fraction of patients responding to cancer immunotherapy, a better understanding of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart the fibroblastic landscape during pancreatic...
7.
Chang J, Durinck S, Chen M, Martinez-Martin N, Zhang J, Lehoux I, et al.
Sci Rep
. 2019 Jun;
9(1):8833.
PMID: 31222070
In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in...
8.
Kategaya L, Di Lello P, Rouge L, Pastor R, Clark K, Drummond J, et al.
Nature
. 2017 Oct;
550(7677):534-538.
PMID: 29045385
The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to substrate proteins as monomers or chains and the topology of ubiquitin modifications regulates substrate interactions with specific...
9.
Bainbridge T, Dunshee D, Kljavin N, Skelton N, Sonoda J, Ernst J
Sci Rep
. 2017 Oct;
7(1):12524.
PMID: 28970566
Fibroblast Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in activated fibroblasts associated with tissue remodeling in various common diseases such as cancer, arthritis and...
10.
Lo M, Kim H, Tong R, Bainbridge T, Vernes J, Zhang Y, et al.
J Biol Chem
. 2017 Jan;
292(9):3900-3908.
PMID: 28077575
The antibody Fc region regulates antibody cytotoxic activities and serum half-life. In a therapeutic context, however, the cytotoxic effector function of an antibody is often not desirable and can create...