James A Ernst
Overview
Explore the profile of James A Ernst including associated specialties, affiliations and a list of published articles.
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31
Citations
2118
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Recent Articles
1.
Ayalon G, Lee S, Adolfsson O, Foo-Atkins C, Atwal J, Blendstrup M, et al.
Sci Transl Med
. 2021 May;
13(593).
PMID: 33980574
Tau has become an attractive alternative target for passive immunotherapy efforts for Alzheimer's disease (AD). The anatomical distribution and extent of tau pathology correlate with disease course and severity better...
2.
Meilandt W, Maloney J, Imperio J, Lalehzadeh G, Earr T, Crowell S, et al.
Alzheimers Res Ther
. 2019 Dec;
11(1):97.
PMID: 31787113
Background: Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer's disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab...
3.
Chang J, Durinck S, Chen M, Martinez-Martin N, Zhang J, Lehoux I, et al.
Sci Rep
. 2019 Jun;
9(1):8833.
PMID: 31222070
In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in...
4.
Chung S, Nguyen V, Lin Y, Lafrance-Vanasse J, Scales S, Lin K, et al.
MAbs
. 2019 Apr;
11(5):942-955.
PMID: 30982394
A cell-based assay employing Madin-Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under...
5.
Vance N, Zacharias N, Ultsch M, Li G, Fourie A, Liu P, et al.
Bioconjug Chem
. 2018 Dec;
30(1):148-160.
PMID: 30566343
Site-specific conjugation of small molecules to antibodies represents an attractive goal for the development of more homogeneous targeted therapies and diagnostics. Most site-specific conjugation strategies require modification or removal of...
6.
Dicara D, Andersen N, Chan R, Ernst J, Ayalon G, Lazar G, et al.
MAbs
. 2018 Aug;
10(7):1073-1083.
PMID: 30130444
Developability assessment of therapeutic antibody candidates assists drug discovery by enabling early identification of undesirable instabilities. Rapid chemical stability screening of antibody variants can accelerate the identification of potential solutions....
7.
Kategaya L, Di Lello P, Rouge L, Pastor R, Clark K, Drummond J, et al.
Nature
. 2017 Oct;
550(7677):534-538.
PMID: 29045385
The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is ligated to substrate proteins as monomers or chains and the topology of ubiquitin modifications regulates substrate interactions with specific...
8.
Kim H, Dunshee D, Yee A, Tong R, Kim I, Farahi F, et al.
Protein Eng Des Sel
. 2017 Oct;
30(9):627-637.
PMID: 28985411
Bispecific antibodies offer a clinically validated platform for drug discovery. In generating functionally active bispecific antibodies, it is necessary to identify a unique parental antibody pair to merge into a...
9.
Bainbridge T, Dunshee D, Kljavin N, Skelton N, Sonoda J, Ernst J
Sci Rep
. 2017 Oct;
7(1):12524.
PMID: 28970566
Fibroblast Activation Protein (FAP) is a membrane-bound serine protease whose expression is often elevated in activated fibroblasts associated with tissue remodeling in various common diseases such as cancer, arthritis and...
10.
Lo M, Kim H, Tong R, Bainbridge T, Vernes J, Zhang Y, et al.
J Biol Chem
. 2017 Jan;
292(9):3900-3908.
PMID: 28077575
The antibody Fc region regulates antibody cytotoxic activities and serum half-life. In a therapeutic context, however, the cytotoxic effector function of an antibody is often not desirable and can create...