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Torsten Steinmetzer

Explore the profile of Torsten Steinmetzer including associated specialties, affiliations and a list of published articles. Areas
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Articles 111
Citations 1755
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Recent Articles
1.
Schwerdtner M, Schmacke L, Nave J, Limburg H, Steinmetzer T, Stein D, et al.
Viruses . 2024 Nov; 16(11). PMID: 39599912
The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) may result in severe disease. Cleavage of the surface glycoproteins hemagglutinin (HA) and spike protein (S), respectively, is essential...
2.
Maluck S, Bobrovsky R, Poor M, Lange R, Steinmetzer T, Jerzsele A, et al.
Biomedicines . 2024 Sep; 12(9). PMID: 39335588
Inhibitors of the serine protease furin have been widely studied as antimicrobial agents due to their ability to block the cleavage and activation of certain viral surface proteins and bacterial...
3.
Brands J, Bravo S, Jurgenliemke L, Gratz L, Schihada H, Frechen F, et al.
Nat Commun . 2024 Sep; 15(1):7684. PMID: 39227390
A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca in living cells is exclusive to Gq- and Gi-sensitive...
4.
Wiedemeyer S, Wu G, Lang-Henkel H, Whisstock J, Law R, Steinmetzer T
ChemMedChem . 2024 Aug; 19(23):e202400360. PMID: 39118493
Two series of macrocyclic inhibitors addressing the S1 pocket and the prime site of the fibrinolytic serine protease plasmin have been developed. In the first series, a P1 tranexamoyl residue...
5.
Gamba D, van Eijk N, Lanyi K, Monostory K, Steinmetzer T, Marosi A, et al.
Sci Rep . 2024 Jul; 14(1):16621. PMID: 39025978
Certain corona- and influenza viruses utilize type II transmembrane serine proteases for cell entry, making these enzymes potential drug targets for the treatment of viral respiratory infections. In this study,...
6.
Bestle D, Bittel L, Werner A, Kamper L, Dolnik O, Krahling V, et al.
Virus Res . 2024 Jul; 347:199430. PMID: 38964470
A multistep priming process involving furin and endosomal cathepsin B and L (CatB/L) has been described for the Orthoebolavirus zairense (EBOV) glycoprotein GP. Inhibition or knockdown of either furin or...
7.
Huber S, Braun N, Schmacke L, Murra R, Bender D, Hildt E, et al.
Arch Pharm (Weinheim) . 2024 May; 357(9):e2400250. PMID: 38809037
Three new series of macrocyclic active site-directed inhibitors of the Zika virus (ZIKV) NS2B-NS3 protease were synthesized. First, attempts were made to replace the basic P3 lysine residue of our...
8.
van Niekerk A, Maluck S, Mag P, Kovago C, Kerek A, Jerzsele A, et al.
Biomedicines . 2024 Apr; 12(4). PMID: 38672139
The increasing prevalence of antimicrobial resistance against zoonotic bacteria, including , highlights the need for new therapeutical strategies, including the repositioning of drugs. In this study, susceptibilities of bacterial isolates...
9.
Heindl M, Rupp A, Schwerdtner M, Bestle D, Harbig A, De Rocher A, et al.
J Virol . 2024 Mar; 98(4):e0010224. PMID: 38470058
The transmembrane serine protease 2 (TMPRSS2) activates the outer structural proteins of a number of respiratory viruses including influenza A virus (IAV), parainfluenza viruses, and various coronaviruses for membrane fusion....
10.
Lange R, Bloch K, Heindl M, Wollenhaupt J, Weiss M, Brandstetter H, et al.
ChemMedChem . 2024 Feb; 19(9):e202400057. PMID: 38385828
A 1H-isoindol-3-amine was identified as suitable P1 group for the proprotein convertase furin using a crystallographic screening with a set of 20 fragments known to occupy the S1 pocket of...