Tony McBryan
Overview
Explore the profile of Tony McBryan including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1266
Followers
0
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Recent Articles
1.
MacKenzie D, Robertson N, Rather I, Reid C, Sendzikaite G, Cruickshanks H, et al.
iScience
. 2020 Feb;
23(2):100838.
PMID: 32058953
Approximately 10% of human colorectal cancer (CRC) are associated with activated BRAFV600E mutation, typically in absence of APC mutation and often associated with a CpG island methylator (CIMP) phenotype. To...
2.
Casciano J, Perry C, Cohen-Nowak A, Miller K, Vande Voorde J, Zhang Q, et al.
Br J Cancer
. 2020 Jan;
122(6):868-884.
PMID: 31942031
Background: Recent studies have suggested that fatty acid oxidation (FAO) is a key metabolic pathway for the growth of triple negative breast cancers (TNBCs), particularly those that have high expression...
3.
van Tuyn J, Jaber-Hijazi F, MacKenzie D, Cole J, Mann E, Pawlikowski J, et al.
J Invest Dermatol
. 2017 Jun;
137(10):2197-2207.
PMID: 28647344
On acquisition of an oncogenic mutation, primary human and mouse cells can enter oncogene-induced senescence (OIS). OIS is characterized by a stable proliferation arrest and secretion of proinflammatory cytokines and...
4.
Cole J, Robertson N, Rather M, Thomson J, McBryan T, Sproul D, et al.
Genome Biol
. 2017 Mar;
18(1):58.
PMID: 28351383
Background: Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions...
5.
Nelson D, Jaber-Hijazi F, Cole J, Robertson N, Pawlikowski J, Norris K, et al.
Genome Biol
. 2016 Jul;
17(1):158.
PMID: 27457071
Background: Histone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear, although H4K20me3 abundance increases during cellular senescence, a stable proliferation...
6.
Rai T, Cole J, Nelson D, Dikovskaya D, Faller W, Vizioli M, et al.
Genes Dev
. 2014 Dec;
28(24):2712-25.
PMID: 25512559
Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular senescence and associated tumor suppression depend on control of chromatin. Histone chaperone HIRA deposits variant histone H3.3 and histone...
7.
Lund K, Cole J, VanderKraats N, McBryan T, Pchelintsev N, Clark W, et al.
Genome Biol
. 2014 Oct;
15(8):406.
PMID: 25315154
Background: Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are neoplastic disorders of hematopoietic stem cells. DNA methyltransferase inhibitors, 5-azacytidine and 5-aza-2'-deoxycytidine (decitabine), benefit some MDS/AML patients. However, the role...
8.
Nelson D, McBryan T, Jeyapalan J, Sedivy J, Adams P
Age (Dordr)
. 2014 Mar;
36(3):9637.
PMID: 24647599
Cellular senescence is a stable proliferation arrest associated with an altered secretory pathway, the senescence-associated secretory phenotype. However, cellular senescence is initiated by diverse molecular triggers, such as activated oncogenes...
9.
Hofmann J, McBryan T, Adams P, Sedivy J
Age (Dordr)
. 2014 Feb;
36(3):9618.
PMID: 24488586
The Wnt signaling pathway is involved in the regulation of tissue patterning and organ development during embryogenesis and continues to contribute to the maintenance of tissue homeostasis in adulthood. Recently,...
10.
Cruickshanks H, McBryan T, Nelson D, VanderKraats N, Shah P, van Tuyn J, et al.
Nat Cell Biol
. 2013 Nov;
15(12):1495-506.
PMID: 24270890
Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes a limit on the proliferative...