Tonnie Huijs
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Explore the profile of Tonnie Huijs including associated specialties, affiliations and a list of published articles.
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10
Citations
146
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Recent Articles
1.
Rao S, Romal S, Torenvliet B, Slotman J, Huijs T, Mahmoudi T
Heliyon
. 2024 May;
10(10):e30740.
PMID: 38770342
Malaria, a major public health burden, is caused by spp parasites that first replicate in the human liver to establish infection before spreading to erythrocytes. Liver-stage malaria research has remained...
2.
Dechering K, Timmerman M, Rensen K, Koolen K, Honarnejad S, Vos M, et al.
SLAS Discov
. 2022 Jul;
27(6):337-348.
PMID: 35872229
A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism...
3.
de Vries L, Jansen P, Barcelo C, Munro J, Verhoef J, Pasaje C, et al.
Nat Commun
. 2022 Apr;
13(1):2158.
PMID: 35444200
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclinical development. Our...
4.
Siciliano G, Di Paolo V, Rotili D, Migale R, Pedini F, Casella M, et al.
Pharmaceuticals (Basel)
. 2022 Feb;
15(2).
PMID: 35215282
This work describes the activity of 6-((7-nitrobenzo[][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX) and of its newly identified carboxylic acid metabolite on the human malaria parasite . NBDHEX has been previously identified as a potent...
5.
Shieh A, Ma C, Chun R, Wittwer-Schegg J, Swinkels L, Huijs T, et al.
J Clin Endocrinol Metab
. 2018 Jun;
103(9):3368-3375.
PMID: 29931358
Context: The physiologic role of free 25-hydroxyvitamin D [25(OH)D] in humans is unclear. Objective: To assess whether rise in total vs free 25(OH)D is associated with change in downstream biomarkers...
6.
Shieh A, Ma C, Chun R, Witzel S, Rafison B, Contreras H, et al.
J Clin Endocrinol Metab
. 2017 Feb;
102(4):1133-1140.
PMID: 28187226
Context: Vitamin D deficiency disproportionately affects nonwhite individuals. Controversy persists over how to best restore low 25D levels, and how to best define vitamin D status [total (protein bound plus...
7.
Chun R, Hernandez I, Pereira R, Swinkles L, Huijs T, Zhou R, et al.
Endocrinology
. 2016 Jul;
157(9):3420-30.
PMID: 27399876
25-Hydroxyvitamin D (25D) circulates bound primarily to serum vitamin D binding protein (DBP), with DBP showing higher binding affinity for 25D3 than 25D2. We therefore hypothesized that vitamin D2 (D2)...
8.
Shieh A, Chun R, Ma C, Witzel S, Meyer B, Rafison B, et al.
J Clin Endocrinol Metab
. 2016 May;
101(8):3070-8.
PMID: 27192696
Context: Controversy persists over: 1) how best to restore low serum 25-hydroxyvitamin D (25D) levels (vitamin D2 [D2] vs vitamin D3 [D3]); 2) how best to define vitamin D status...
9.
van den Berk L, Roelofs H, Huijs T, Siebers-Vermeulen K, Raymakers R, Kogler G, et al.
Immunology
. 2009 Nov;
128(4):564-72.
PMID: 19930046
Pathogen-derived entities force the tissue-resident dendritic cells (DCs) towards a mature state, followed by migration to the draining lymph node to present antigens to T cells. Bone marrow mesenchymal stem...
10.
den Dekker E, Grefte S, Huijs T, Ten Dam G, Versteeg E, van den Berk L, et al.
J Immunol
. 2008 Mar;
180(6):3680-8.
PMID: 18322173
IL-4 induces the differentiation of monocytes toward dendritic cells (DCs). The activity of many cytokines is modulated by glycosaminoglycans (GAGs). In this study, we explored the effect of GAGs on...