Effects of Cholecalciferol Vs Calcifediol on Total and Free 25-Hydroxyvitamin D and Parathyroid Hormone

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2017 Feb 11

PMID 28187226

Citations 25

Authors

Albert Shieh

Christina Ma

Rene F Chun

Sten Witzel

Brandon Rafison

Hannah T M Contreras

Jonas Wittwer-Schegg

Leon Swinkels

Tonnie Huijs

Martin Hewison

John S Adams

Affiliations

Soon will be listed here.

Abstract

Context: Vitamin D deficiency disproportionately affects nonwhite individuals. Controversy persists over how to best restore low 25D levels, and how to best define vitamin D status [total (protein bound plus free) vs free 25D].

Objective: To assess the effects of vitamin D3 (cholecalciferol, or D3) vs 25-hydroxyvitamin D3 (calcifediol, or 25D3) on total and free 25D in a multiethnic cohort of adults, and whether change in parathyroid hormone (PTH) is more strongly associated with total vs free 25D.

Design: Sixteen-week randomized controlled trial. Biochemistries at 0, 4, 8, and 16 weeks.

Setting: Academic medical center.

Participants: Thirty-five adults ≥18 years of age with 25D levels <20 ng/mL.

Intervention: Sixty micrograms (2400 IU)/d of D3 or 20 μg/d of 25D3.

Main Outcome Measures: Total and free 25D, and PTH.

Results: Baseline total (16.2 ± 3.7 vs 17.0 ± 2.5 ng/mL; P = 0.4) and free (4.2 ± 0.8 vs 4.7 ± 1.0 pg/mL; P = 0.2) 25D were similar between D3 and 25D3 groups, respectively; 25D3 increased total (+25.5 vs +13.8 ng/mL; P = 0.001) and free (+6.6 vs +3.5 pg/mL; P = 0.03) 25D more than D3. By 4 weeks, 87.5% of 25D3 participants had total 25D levels ≥30 ng/mL, compared with 23.1% of D3 participants (P = 0.001). Change in PTH was associated with both total (P = 0.01) and free 25D (P = 0.04).

Conclusions: 25D3 increased total and free 25D levels more rapidly than D3, regardless of race/ethnicity. Free and total 25D were similarly associated with change in PTH.

Citing Articles

Effect of cholecalciferol versus calcifediol on serum 25(OH)D concentrations: a systematic review with meta-analysis.

Bouden S, Ben Messaoud M, Saidane O, Rouached L, Ben Tekaya A, Mahmoud I Eur J Clin Nutr. 2024; .

PMID: 39385006 DOI: 10.1038/s41430-024-01520-x.

Native vitamin D in CKD and renal transplantation: meaning and rationale for its supplementation.

Alfieri C, Molinari P, Vettoretti S, Fusaro M, Bover J, Cianciolo G J Nephrol. 2024; 37(6):1477-1485.

PMID: 39223353 DOI: 10.1007/s40620-024-02055-x.

Effect of 2 Years of Monthly Calcifediol Administration in Postmenopausal Women with Vitamin D Insufficiency.

Occhiuto M, Pepe J, Colangelo L, Lucarelli M, Angeloni A, Nieddu L Nutrients. 2024; 16(11).

PMID: 38892687 PMC: 11174435. DOI: 10.3390/nu16111754.

Impact of BMI on serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with calcifediol supplementation in young adults: a longitudinal study.

Das L, Sachdeva N, Holick M, Devnani M, Dutta P, Marwaha R Endocrine. 2024; 86(1):391-399.

PMID: 38861119 DOI: 10.1007/s12020-024-03895-0.

Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate.

Turck D, Bohn T, Castenmiller J, de Henauw S, Hirsch-Ernst K, Knutsen H EFSA J. 2023; 21(8):e08145.

PMID: 37560437 PMC: 10407748. DOI: 10.2903/j.efsa.2023.8145.

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