Tomoko Nishiyama
Overview
Explore the profile of Tomoko Nishiyama including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
860
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Recent Articles
1.
Prusen Mota I, Galova M, Schleiffer A, Nguyen T, Kovacikova I, Farias Saad C, et al.
Nat Commun
. 2024 Jun;
15(1):4729.
PMID: 38830897
Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA....
2.
Tane S, Shintomi K, Kinoshita K, Tsubota Y, Yoshida M, Nishiyama T, et al.
Elife
. 2022 Dec;
11.
PMID: 36511239
Condensin I is a pentameric protein complex that plays an essential role in mitotic chromosome assembly in eukaryotic cells. Although it has been shown that condensin I loading is mitosis...
3.
Kinoshita K, Tsubota Y, Tane S, Aizawa Y, Sakata R, Takeuchi K, et al.
J Cell Biol
. 2022 Jan;
221(3).
PMID: 35045152
Condensin I is a five-subunit protein complex that is central to mitotic chromosome assembly in eukaryotic cells. Despite recent progress, its molecular mechanisms of action remain to be fully elucidated....
4.
Sakata R, Niwa K, Ugarte La Torre D, Gu C, Tahara E, Takada S, et al.
Cell Rep
. 2021 Apr;
35(4):108999.
PMID: 33909997
The ring-shaped cohesin complex topologically binds to DNA to establish sister chromatid cohesion. This topological binding creates a structural obstacle to genome-wide chromosomal events, such as replication. Here, we examine...
5.
Nishiyama T
Mol Cell
. 2019 Jul;
75(2):201-203.
PMID: 31348876
Sister chromatid cohesion has been thought to be mediated by DNA entrapment within the large cohesin ring. Vazquez Nunez et al. and Chapard et al. now show that the ring...
6.
Nishiyama T
Curr Opin Cell Biol
. 2018 Dec;
58:8-14.
PMID: 30544080
Cohesin, one of structural maintenance of chromosomes (SMC) complexes, forms a ring-shaped protein complex, and mediates sister chromatid cohesion for accurate chromosome segregation and precise genome inheritance. The cohesin ring...
7.
Hirano T, Nishiyama T, Shirahige K
Genes Cells
. 2017 Oct;
22(11):934-938.
PMID: 29067760
The second international meeting on "SMC proteins: Chromosomal Organizers from Bacteria to Human" (SMC2017) was held in Nanyo City, Yamagata, Japan, from 13 to 16 June 2017. The meeting was...
8.
Yamada T, Tahara E, Kanke M, Kuwata K, Nishiyama T
EMBO J
. 2017 May;
36(11):1513-1527.
PMID: 28483815
Sister chromatid cohesion is crucial to ensure chromosome bi-orientation and equal chromosome segregation. Cohesin removal via mitotic kinases and Wapl has to be prevented in pericentromeric regions in order to...
9.
Kanke M, Tahara E, Huis Int Veld P, Nishiyama T
EMBO J
. 2016 Nov;
35(24):2686-2698.
PMID: 27872142
Cohesin is a ring-shaped protein complex that plays a crucial role in sister chromatid cohesion and gene expression. The dynamic association of cohesin with chromatin is essential for these functions....
10.
Tedeschi A, Wutz G, Huet S, Jaritz M, Wuensche A, Schirghuber E, et al.
Nature
. 2013 Aug;
501(7468):564-8.
PMID: 23975099
Mammalian genomes contain several billion base pairs of DNA that are packaged in chromatin fibres. At selected gene loci, cohesin complexes have been proposed to arrange these fibres into higher-order...