Katsuhiko Shirahige
Overview
Explore the profile of Katsuhiko Shirahige including associated specialties, affiliations and a list of published articles.
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227
Citations
11779
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Recent Articles
1.
Sakata T, Tei S, Izumi K, Krantz I, Bando M, Shirahige K
Curr Biol
. 2025 Feb;
PMID: 39983729
The cohesin protein complex is essential for the formation of topologically associating domains (TADs) and chromatin loops on interphase chromosomes. For the loading onto chromosomes, cohesin requires the cohesin loader...
2.
Saijou E, Kamiya Y, Fujiki K, Shirahige K, Nakato R
Heliyon
. 2024 Sep;
10(17):e36727.
PMID: 39296030
Liver fibrosis is a critical global health challenge, often leading to severe liver diseases without timely intervention. Choline deficiency has been linked to metabolic dysfunction associated steatohepatitis (MASH) and liver...
3.
Kline A, Krantz I, Bando M, Shirahige K, Chea S, Sakata T, et al.
Am J Med Genet A
. 2024 Jul;
179(6):1080-1090.
PMID: 39070592
Cornelia de Lange Syndrome (CdLS), due to mutations in genes of the cohesin protein complex, is described as a disorder of transcriptional regulation. Phenotypes in this expanding field include short...
4.
Nagagaki Y, Kozakura Y, Mahandaran T, Fumoto Y, Nakato R, Shirahige K, et al.
Genes Cells
. 2024 Jul;
29(9):722-734.
PMID: 38977420
Appropriate responses to environmental challenges are imperative for the survival of all living organisms. Exposure to low-dose stresses is recognized to yield increased cellular fitness, a phenomenon termed hormesis. However,...
5.
Iwata-Otsubo A, Skraban C, Yoshimura A, Sakata T, Alves C, Fiordaliso S, et al.
Hum Genet
. 2024 Mar;
143(3):437-453.
PMID: 38520561
General transcription factor IIIC subunit 5 (GTF3C5) encodes transcription factor IIIC63 (TFIIIC63). It binds to DNA to recruit another transcription factor, TFIIIB, and RNA polymerase III (Pol III) to mediate...
6.
Fukuda M, Fujita Y, Hino Y, Nakao M, Shirahige K, Yamashita T
Int J Mol Sci
. 2024 Mar;
25(5).
PMID: 38473789
In the adult mammalian brain, neurons are produced from neural stem cells (NSCs) residing in two niches-the subventricular zone (SVZ), which forms the lining of the lateral ventricles, and the...
7.
Jeppsson K, Pradhan B, Sutani T, Sakata T, Umeda Igarashi M, Berta D, et al.
Mol Cell
. 2024 Jan;
84(5):867-882.e5.
PMID: 38295804
The structural maintenance of chromosomes (SMC) protein complexes-cohesin, condensin, and the Smc5/6 complex (Smc5/6)-are essential for chromosome function. At the molecular level, these complexes fold DNA by loop extrusion. Accordingly,...
8.
Homma M, Nakato R, Niida A, Bando M, Fujiki K, Yokota N, et al.
Life Sci Alliance
. 2023 Oct;
7(1).
PMID: 37907238
Nuclear expression of protein kinase CK2α is reportedly elevated in human carcinomas, but mechanisms underlying its variable localization in cells are poorly understood. This study demonstrates a functional connection between...
9.
Jia H, Miyoshi M, Li X, Furukawa K, Otani L, Shirahige K, et al.
Nutrients
. 2023 Sep;
15(18).
PMID: 37764741
Nutrient imbalances during gestation are a risk factor for hypertension in offspring. Although the effects of prenatal nutritional deficiency on the development of hypertension and cardiovascular diseases in adulthood have...
10.
Nakato R, Sakata T, Wang J, Nagai L, Nagaoka Y, Oba G, et al.
Nat Commun
. 2023 Sep;
14(1):5647.
PMID: 37726281
Cohesin regulates gene expression through context-specific chromatin folding mechanisms such as enhancer-promoter looping and topologically associating domain (TAD) formation by cooperating with factors such as cohesin loaders and the insulation...