Tomoki Imaoka
Overview
Explore the profile of Tomoki Imaoka including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
293
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0
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Recent Articles
1.
Imaoka T, Onuki-Nagasaki R, Kimura H, Tai K, Ishii M, Nozue A, et al.
Sci Rep
. 2024 Dec;
14(1):29921.
PMID: 39622870
There is an urgent need for novel methods that can accurately predict intestinal absorption of orally administered drugs in humans. This study aimed to evaluate the potential of a novel...
2.
Taniguchi T, Yasumatsu I, Inagaki H, Baba D, Toyota A, Kaneta Y, et al.
ACS Med Chem Lett
. 2024 Jul;
15(7):1010-1016.
PMID: 39015278
Previously, we reported the new pyrido-pyridazinone template as a feline sarcoma-related (FER) tyrosine kinase inhibitor. Representative compound () showed strong enzyme inhibitory activity (IC50 = 0.5 nM), however, its antitumor...
3.
Michiba K, Watanabe K, Imaoka T, Nakai D
Pharmaceutics
. 2024 Jan;
16(1).
PMID: 38258048
Intestinal absorption is a complex process involving the permeability of the epithelial barrier, efflux transporter activity, and intestinal metabolism. Identifying the key factors that govern intestinal absorption for each investigational...
4.
Yamamura N, Imaoka T, Hoshi M, Yamada M, Itokawa K
Xenobiotica
. 2023 Jan;
53(2):114-122.
PMID: 36715563
Cimetidine at a clinical dosage decreased the renal clearance (CLr) of mirogabalin in humans by inhibition of renal secretion. Mirogabalin is a substrate of human OAT1/3, OCT2, MATE1 and/or MATE2-K....
5.
Imaoka T, Huang W, Shum S, Hailey D, Chang S, Chapron A, et al.
Sci Rep
. 2021 Nov;
11(1):21356.
PMID: 34725352
Opioid overdose, dependence, and addiction are a major public health crisis. Patients with chronic kidney disease (CKD) are at high risk of opioid overdose, therefore novel methods that provide accurate...
6.
Arian C, Imaoka T, Yang J, Kelly E, Thummel K
Pharmacol Ther
. 2021 Sep;
230:107962.
PMID: 34478775
The intestine has important gate-keeping functions that can profoundly affect the systemic blood exposure of orally administered drugs. Thus, characterizing a new molecular entity's (NME) disposition within the intestine is...
7.
Imaoka T, Yang J, Wang L, McDonald M, Afsharinejad Z, Bammler T, et al.
Toxicology
. 2020 Sep;
444:152582.
PMID: 32905824
Ochratoxin A (OTA) is one of the most abundant mycotoxin contaminants in food stuffs and possesses carcinogenic, nephrotoxic, teratogenic, and immunotoxic properties. Specifically, a major concern is severe nephrotoxicity, which...
8.
Chapron A, Chapron B, Hailey D, Chang S, Imaoka T, Thummel K, et al.
ACS Pharmacol Transl Sci
. 2020 Jun;
3(3):496-508.
PMID: 32566915
A vascularized human proximal tubule model in a dual-channel microphysiological system (VPT-MPS) was developed, representing an advance over previous, single-cell-type kidney microphysiological systems. Human proximal tubule epithelial cells (PTECs) and...
9.
Machida Y, Nakagawa M, Matsunaga H, Yamaguchi M, Ogawara Y, Shima Y, et al.
Mol Cancer Ther
. 2019 Nov;
19(2):375-383.
PMID: 31727689
Gliomas are the second most common primary brain tumors in adults. They are treated with combination therapies, including surgery, radiotherapy, and chemotherapy. There are currently limited treatment options for recurrent...
10.
Taniguchi T, Inagaki H, Baba D, Yasumatsu I, Toyota A, Kaneta Y, et al.
ACS Med Chem Lett
. 2019 May;
10(5):737-742.
PMID: 31097992
To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound , which has a pyridine moiety, was found....