Tomokatsu Iwamura
Overview
Explore the profile of Tomokatsu Iwamura including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
95
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0
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Recent Articles
1.
Yokokawa H, Shinohara M, Teraoka Y, Imamura M, Nakamura N, Watanabe N, et al.
PLoS One
. 2022 Sep;
17(9):e0274283.
PMID: 36137152
In recent years, new direct-acting antivirals for hepatitis C virus (HCV) have been approved, but hepatitis C continues to pose a threat to human health. It is important to develop...
2.
Tsuge M, Uchida T, Hiraga N, Kan H, Makokha G, Abe-Chayama H, et al.
Antimicrob Agents Chemother
. 2017 Apr;
61(6).
PMID: 28373196
Although nucleot(s)ide analogues and pegylated interferon alpha 2a (PEG-IFN-α2a) can suppress hepatitis B virus (HBV) replication, it is difficult to achieve complete HBV elimination from hepatocytes. A novel site-specific pegylated...
3.
Iwamura T, Narumi H, Suzuki T, Yanai H, Mori K, Yamashita K, et al.
Cancer Sci
. 2017 Jan;
108(4):581-589.
PMID: 28129467
Malignant ascites manifests as an end-stage event during the progression of a number of cancers and lacks a generally accepted standard therapy. Interferon-β (IFN-β) has been used to treat several...
4.
Kubota N, Kubota T, Kajiwara E, Iwamura T, Kumagai H, Watanabe T, et al.
Nat Commun
. 2016 Oct;
7:12977.
PMID: 27708333
Hepatic insulin signalling involves insulin receptor substrates (Irs) 1/2, and is normally associated with the inhibition of gluconeogenesis and activation of lipogenesis. In diabetes and obesity, insulin no longer suppresses...
5.
Kubota T, Kubota N, Sato H, Inoue M, Kumagai H, Iwamura T, et al.
Sci Rep
. 2016 Oct;
6:34707.
PMID: 27703271
The aim of this study is to elucidate to what degree adiponectin is involved in TZD-mediated amelioration of neointimal formation. We investigated the effect of 3- or 8-weeks' pioglitazone on...
6.
Okazaki S, Takahashi T, Iwamura T, Nakaki J, Sekiya Y, Yagi M, et al.
J Pharmacol Exp Ther
. 2014 Aug;
351(1):181-9.
PMID: 25100752
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is considered a potential therapeutic target in the treatment of type 2 diabetes mellitus. In this study, we investigated the pharmacological properties of HIS-388 (N-[(1R,2s,3S,5s,7s)-5-hydroxyadamantan-2-yl]-3-(pyridin-2-yl)...
7.
Udagawa S, Sakami S, Takemura T, Sato M, Arai T, Nitta A, et al.
Bioorg Med Chem Lett
. 2013 Feb;
23(6):1617-21.
PMID: 23414800
A series of novel 5-trans-hydroxyadamantan-2-yl-5,6,7,8-tetrahydropyrazolo[4,3-c]azepin-4(1H)-ones that inhibit 11beta-hydroxysteroid dehydrogenase type 1 are described. We discovered these 7-membered cyclic amide derivatives by introducing a distinctive linker through pharmacophore analysis of known...
8.
Shinobu N, Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Fukuhara Y, et al.
FEBS Lett
. 2002 Jun;
517(1-3):251-6.
PMID: 12062447
Infections of bacteria and viruses induce host defense reactions known as innate responses that include the production of cytokines and chemokines. The production of type I interferon (IFN) is known...