Tomas Knedlik
Overview
Explore the profile of Tomas Knedlik including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
81
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0
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Recent Articles
1.
Norouzi Esfahani E, Knedlik T, Shin S, Magalhaes Rebelo A, De Mario A, Vianello C, et al.
Biomolecules
. 2025 Jan;
15(1).
PMID: 39858520
Neural progenitor cells (NPCs) are often used to study the subcellular mechanisms underlying differentiation into neurons in vitro. Works published to date have focused on the pathways that distinguish undifferentiated...
2.
Knedlik T, Giacomello M
Nat Cell Biol
. 2024 Nov;
26(11):1822-1824.
PMID: 39482355
No abstract available.
3.
Vianello C, Dal Bello F, Shin S, Schiavon S, Bean C, Magalhaes Rebelo A, et al.
Cells
. 2023 Apr;
12(7).
PMID: 37048162
Recent proteomic, metabolomic, and transcriptomic studies have highlighted a connection between changes in mitochondria physiology and cellular pathophysiological mechanisms. Secondary assays to assess the function of these organelles appear fundamental...
4.
Cagnin S, Knedlik T, Vianello C, Magalhaes Rebelo A, De Mario A, Giacomello M
Biomedicines
. 2023 Feb;
11(2).
PMID: 36831133
Neuroblastoma (NB) is the most common extracranial tumor of early childhood and accounts for 15% of all pediatric cancer mortalities. However, the precise pathways and genes underlying its progression are...
5.
Knedlik T, Giacomello M
Biomolecules
. 2022 Oct;
12(10).
PMID: 36291623
Mitochondria are semi-autonomous, membrane-bound organelles present in the cytoplasm of nearly all eukaryotic cells [...].
6.
Magalhaes Rebelo A, Dal Bello F, Knedlik T, Kaar N, Volpin F, Shin S, et al.
Cells
. 2020 Jul;
9(7).
PMID: 32646031
Contact sites between mitochondria and endoplasmic reticulum (ER) are points in which the two organelles are in close proximity. Due to their structural and functional complexity, their exploitation as pharmacological...
7.
Vorlova B, Knedlik T, Tykvart J, Konvalinka J
Front Biosci (Landmark Ed)
. 2019 Mar;
24(4):648-687.
PMID: 30844704
Glutamate carboxypeptidases II and III (GCPII and GCPIII) are highly homologous di-zinc metallopeptidases belonging to the M28 family. These enzymes are expressed in a variety of tissues, including the brain,...
8.
Simon P, Knedlik T, Blazkova K, Dvorakova P, Brezinova A, Kostka L, et al.
ACS Chem Biol
. 2018 Nov;
13(12):3333-3342.
PMID: 30489064
Identifying protein targets of bioactive small molecules often requires complex, lengthy development of affinity probes. We present a method for stochastic modification of small molecules of interest with a photoactivatable...
9.
Dvorakova P, Busek P, Knedlik T, Schimer J, Etrych T, Kostka L, et al.
J Med Chem
. 2017 Sep;
60(20):8385-8393.
PMID: 28953383
Proteases are directly involved in cancer pathogenesis. Expression of fibroblast activation protein (FAP) is upregulated in stromal fibroblasts in more than 90% of epithelial cancers and is associated with tumor...
10.
Knedlik T, Vorlova B, Navratil V, Tykvart J, Sedlak F, Vaculin S, et al.
FEBS Open Bio
. 2017 Sep;
7(9):1362-1378.
PMID: 28904865
Glutamate carboxypeptidase II (GCPII), also known as prostate-specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human brain and prostate. GCPII expression is considerably increased...