Comparison Among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2023 Feb 25

PMID 36831133

Authors

Stefano Cagnin

Tomas Knedlik

Caterina Vianello

Ana Paula Magalhaes Rebelo

Agnese De Mario

Marta Giacomello

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma (NB) is the most common extracranial tumor of early childhood and accounts for 15% of all pediatric cancer mortalities. However, the precise pathways and genes underlying its progression are unknown. Therefore, we performed a differential gene expression analysis of neuroblastoma stage 1 and stage 4 + 4S to discover biological processes associated with NB progression. From this preliminary analysis, we found that NB samples (stage 4 + 4S) are characterized by altered expression of some proteins involved in mitochondria function and mitochondria-ER contact sites (MERCS). Although further analyses remain necessary, this review may provide new hints to better understand NB molecular etiopathogenesis, by suggesting that MERCS alterations could be involved in the progression of NB.

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