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Tomas Di Domenico

Explore the profile of Tomas Di Domenico including associated specialties, affiliations and a list of published articles. Areas
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Articles 31
Citations 3345
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Recent Articles
1.
Garcia-Vilchez R, Anazco-Guenkova A, Dietmann S, Lopez J, Moron-Calvente V, DAmbrosi S, et al.
Mol Cancer . 2023 Jul; 22(1):119. PMID: 37516825
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition...
2.
Jimenez-Santos M, Garcia-Martin S, Fustero-Torre C, Di Domenico T, Gomez-Lopez G, Al-Shahrour F
Mol Oncol . 2022 Jul; 16(21):3881-3908. PMID: 35811332
Tumour heterogeneity is one of the main characteristics of cancer and can be categorised into inter- or intratumour heterogeneity. This heterogeneity has been revealed as one of the key causes...
3.
Fustero-Torre C, Jimenez-Santos M, Garcia-Martin S, Carretero-Puche C, Garcia-Jimeno L, Ivanchuk V, et al.
Genome Med . 2021 Dec; 13(1):187. PMID: 34911571
We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in...
4.
Garcia-Jimeno L, Fustero-Torre C, Jimenez-Santos M, Gomez-Lopez G, Di Domenico T, Al-Shahrour F
Bioinformatics . 2021 Nov; 38(4):1155-1156. PMID: 34788788
Summary: bollito is an automated, flexible and parallelizable computational pipeline for the comprehensive analysis of single-cell RNA-seq data. Starting from FASTQ files or preprocessed expression matrices, bollito performs both basic...
5.
Rodriguez J, Pozo F, Cerdan-Velez D, Di Domenico T, Vazquez J, Tress M
Nucleic Acids Res . 2021 Nov; 50(D1):D54-D59. PMID: 34755885
APPRIS (https://appris.bioinfo.cnio.es) is a well-established database housing annotations for protein isoforms for a range of species. APPRIS selects principal isoforms based on protein structure and function features and on cross-species...
6.
Pozo F, Martinez-Gomez L, Walsh T, Rodriguez J, Di Domenico T, Abascal F, et al.
NAR Genom Bioinform . 2021 May; 3(2):lqab044. PMID: 34046593
Alternative splicing of messenger RNA can generate an array of mature transcripts, but it is not clear how many go on to produce functionally relevant protein isoforms. There is only...
7.
Lozano R, Salles D, Sandhu S, Aragon I, Thorne H, Lopez-Campos F, et al.
Eur J Cancer . 2021 Feb; 147:74-83. PMID: 33626496
Background: Intraductal (IDC) and cribriform (CRIB) histologies in prostate cancer have been associated with germline BRCA2 (gBRCA2) mutations in small retrospective series, leading to the recommendation of genetic testing for...
8.
Frankish A, Diekhans M, Jungreis I, Lagarde J, Loveland J, Mudge J, et al.
Nucleic Acids Res . 2020 Dec; 49(D1):D916-D923. PMID: 33270111
The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics. GENCODE annotation...
9.
Salvador-Barbero B, Alvarez-Fernandez M, Zapatero-Solana E, El Bakkali A, Menendez M, Lopez-Casas P, et al.
Cancer Cell . 2020 Oct; 38(4):584. PMID: 33049208
No abstract available.
10.
Rodriguez J, Pozo F, Di Domenico T, Vazquez J, Tress M
PLoS Comput Biol . 2020 Oct; 16(10):e1008287. PMID: 33017396
The role of alternative splicing is one of the great unanswered questions in cellular biology. There is strong evidence for alternative splicing at the transcript level, and transcriptomics experiments show...