Tom V Lee
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Explore the profile of Tom V Lee including associated specialties, affiliations and a list of published articles.
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20
Citations
788
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Recent Articles
1.
Yu M, Ye H, De-Paula R, Mangleburg C, Wu T, Lee T, et al.
PLoS Genet
. 2023 May;
19(5):e1010760.
PMID: 37200393
Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson's disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and...
2.
Shields A, Amcheslavsky A, Brown E, Lee T, Nie Y, Tanji T, et al.
Cell Rep
. 2022 May;
39(7):110817.
PMID: 35584678
Drosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of the remaining eight Toll-related proteins in Drosophila are not fully understood. Here, we show that Drosophila...
3.
Wan Y, Al-Ouran R, Mangleburg C, Perumal T, Lee T, Allison K, et al.
Cell Rep
. 2020 Jul;
32(2):107908.
PMID: 32668255
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples. We discover 30 brain coexpression...
4.
Satizabal C, Adams H, Hibar D, White C, Knol M, Stein J, et al.
Nat Genet
. 2019 Oct;
51(11):1624-1636.
PMID: 31636452
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus,...
5.
Al-Ouran R, Wan Y, Mangleburg C, Lee T, Allison K, Shulman J, et al.
Genes (Basel)
. 2019 Sep;
10(10).
PMID: 31561642
Target nomination for drug development has been a major challenge in the path to finding a cure for several neurological disorders. Comprehensive transcriptome profiles have revealed brain gene expression changes...
6.
Ojelade S, Lee T, Giagtzoglou N, Yu L, Ugur B, Li Y, et al.
Cell Rep
. 2019 Aug;
28(7):1799-1813.e5.
PMID: 31412248
The Alzheimer's disease (AD) susceptibility gene, CD2-associated protein (CD2AP), encodes an actin binding adaptor protein, but its function in the nervous system is largely unknown. Loss of the Drosophila ortholog...
7.
Pandey A, Li-Kroeger D, Sethi M, Lee T, Buettner F, Bakker H, et al.
Glycobiology
. 2018 Sep;
28(11):849-859.
PMID: 30169771
In multicellular organisms, glycosylation regulates various developmental signaling pathways including the Notch pathway. One of the O-linked glycans added to epidermal growth factor-like (EGF) repeats in animal proteins including the...
8.
Lee T, Pandey A, Jafar-Nejad H
PLoS Genet
. 2017 Apr;
13(4):e1006723.
PMID: 28394891
The Drosophila glucoside xylosyltransferase Shams xylosylates Notch and inhibits Notch signaling in specific contexts including wing vein development. However, the molecular mechanisms underlying context-specificity of the shams phenotype is not...
9.
Servian-Morilla E, Takeuchi H, Lee T, Clarimon J, Mavillard F, Area-Gomez E, et al.
EMBO Mol Med
. 2016 Nov;
8(11):1289-1309.
PMID: 27807076
Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limb-girdle muscular dystrophy, we...
10.
Haltom A, Lee T, Harvey B, Leonardi J, Chen Y, Hong Y, et al.
PLoS Genet
. 2014 Nov;
10(11):e1004795.
PMID: 25412384
The protein O-glucosyltransferase Rumi/POGLUT1 regulates Drosophila Notch signaling by adding O-glucose residues to the Notch extracellular domain. Rumi has other predicted targets including Crumbs (Crb) and Eyes shut (Eys), both...