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Joshua M Shulman

Explore the profile of Joshua M Shulman including associated specialties, affiliations and a list of published articles. Areas
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Articles 90
Citations 6348
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Recent Articles
1.
Moore J, Wu T, Dhindsa J, El Fadel O, Le A, Perez A, et al.
NPJ Parkinsons Dis . 2025 Mar; 11(1):46. PMID: 40069190
Parkinson's disease (PD) starts decades before symptoms appear, usually in the later decades of life, when age-related changes are occurring. To identify molecular changes early in the disease course and...
2.
Spargo T, Sands C, Juan I, Mitchell J, Ravanmehr V, Butts J, et al.
Cell Rep . 2025 Mar; :115355. PMID: 40056900
Despite its significant heritability, the genetic basis of Parkinson's disease (PD) remains incompletely understood. Here, in analyzing whole-genome sequence data from 3,809 PD cases and 247,101 controls in the UK...
3.
Goodman L, Ralhan I, Li X, Lu S, Moulton M, Park Y, et al.
Nat Neurosci . 2024 Aug; 27(10):1918-1933. PMID: 39187706
The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies, defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid production and the...
4.
Paveskovic M, De-Paula R, Ojelade S, Tantry E, Kochukov M, Bao S, et al.
Hum Mol Genet . 2024 Aug; 33(20):1815-1832. PMID: 39146503
CD2-Associated protein (CD2AP) is a candidate susceptibility gene for Alzheimer's disease, but its role in the mammalian central nervous system remains largely unknown. We show that CD2AP protein is broadly...
5.
Buchman A, Yu L, Oveisgharan S, Zammit A, Wang T, Shulman J, et al.
J Alzheimers Dis . 2024 Aug; 100(s1):S197-S209. PMID: 39121125
Background: The interrelationship of parkinsonism, Parkinson's disease (PD) and other Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD) pathologies is unclear. Objective: We examined the progression of parkinsonian...
6.
Smith H, Robinson J, Levchenko A, Pereira S, Pascual B, Bradbury K, et al.
J Alzheimers Dis . 2024 Jan; 97(3):1261-1274. PMID: 38250770
Background: Understanding research participants' responses to learning Alzheimer's disease (AD) risk information is important to inform clinical implementation of precision diagnostics given rapid advances in disease modifying therapies. Objective: We...
7.
Wu T, Deger J, Ye H, Guo C, Dhindsa J, Pekarek B, et al.
Elife . 2023 May; 12. PMID: 37219079
Aging is a major risk factor for Alzheimer's disease (AD), and cell-type vulnerability underlies its characteristic clinical manifestations. We have performed longitudinal, single-cell RNA-sequencing in with pan-neuronal expression of human...
8.
Yu M, Ye H, De-Paula R, Mangleburg C, Wu T, Lee T, et al.
PLoS Genet . 2023 May; 19(5):e1010760. PMID: 37200393
Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson's disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and...
9.
Lagisetty Y, Bourquard T, Al-Ramahi I, Mangleburg C, Mota S, Soleimani S, et al.
Cell Genom . 2022 Oct; 2(9). PMID: 36268052
Most disease-gene association methods do not account for gene-gene interactions, even though these play a crucial role in complex, polygenic diseases like Alzheimer's disease (AD). To discover new genes whose...
10.
Li J, Amoh B, McCormick E, Tarkunde A, Zhu K, Perez A, et al.
Hum Mol Genet . 2022 Sep; 32(4):685-695. PMID: 36173927
Genome-wide association studies (GWAS) have markedly advanced our understanding of the genetics of Parkinson's disease (PD), but they currently do not account for the full heritability of PD. In many...