Tom S Wehrman
Overview
Explore the profile of Tom S Wehrman including associated specialties, affiliations and a list of published articles.
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15
Citations
542
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0
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Recent Articles
1.
Moraga I, Spangler J, Mendoza J, Gakovic M, Wehrman T, Krutzik P, et al.
Elife
. 2017 May;
6.
PMID: 28498099
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation. However, the number of receptor dimer pairings...
2.
Ho C, Chhabra A, Starkl P, Schnorr P, Wilmes S, Moraga I, et al.
Cell
. 2017 Mar;
168(6):1041-1052.e18.
PMID: 28283060
Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines...
3.
Burford N, Livingston K, Canals M, Ryan M, Budenholzer L, Han Y, et al.
J Med Chem
. 2015 Apr;
58(10):4220-9.
PMID: 25901762
Allosteric modulators of G protein-coupled receptors (GPCRs) have a number of potential advantages compared to agonists or antagonists that bind to the orthosteric site of the receptor. These include the...
4.
Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter C, Hong W, et al.
Cell
. 2015 Mar;
160(6):1196-208.
PMID: 25728669
Most cell-surface receptors for cytokines and growth factors signal as dimers, but it is unclear whether remodeling receptor dimer topology is a viable strategy to "tune" signaling output. We utilized...
5.
Rajagopal S, Bassoni D, Campbell J, Gerard N, Gerard C, Wehrman T
J Biol Chem
. 2013 Oct;
288(49):35039-48.
PMID: 24145037
Chemokines display considerable promiscuity with multiple ligands and receptors shared in common, a phenomenon that is thought to underlie their biochemical "redundancy." Their receptors are part of a larger seven-transmembrane...
6.
Burford N, Clark M, Wehrman T, Gerritz S, Banks M, OConnell J, et al.
Proc Natl Acad Sci U S A
. 2013 Jun;
110(26):10830-5.
PMID: 23754417
μ-Opioid receptors are among the most studied G protein-coupled receptors because of the therapeutic value of agonists, such as morphine, that are used to treat chronic pain. However, these drugs...
7.
Southern C, Cook J, Neetoo-Isseljee Z, Taylor D, Kettleborough C, Merritt A, et al.
J Biomol Screen
. 2013 Feb;
18(5):599-609.
PMID: 23396314
A variety of G-protein-coupled receptor (GPCR) screening technologies have successfully partnered a number of GPCRs with their cognate ligands. GPCR-mediated β-arrestin recruitment is now recognized as a distinct intracellular signaling...
8.
Bassoni D, Raab W, Achacoso P, Loh C, Wehrman T
Methods Mol Biol
. 2012 Jun;
897:181-203.
PMID: 22674166
The recruitment of arrestins to activated 7TMRs results in the activation of alternative signaling pathways, quenching of G-protein activation, and coupling to clathrin-mediated endocytosis. The nearly ubiquitous involvement of arrestin...
9.
Bassoni D, Jafri Q, Sastry S, Mathrubutham M, Wehrman T
Methods Mol Biol
. 2012 Jun;
897:171-80.
PMID: 22674165
More than two-thirds of all known G-protein coupled receptors are known to modulate the function of adenylate cyclase resulting in altered levels of cAMP. In turn, cAMP fluctuations transform agonist...
10.
von Degenfeld G, Wehrman T, Blau H
Methods Mol Biol
. 2009 Aug;
574:249-59.
PMID: 19685314
Bioluminescence using the reporter enzyme firefly luciferase (Fluc) and the substrate luciferin enables non-invasive optical imaging of living animals with extremely high sensitivity. This type of analysis enables studies of...