Tom OToole
Overview
Explore the profile of Tom OToole including associated specialties, affiliations and a list of published articles.
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20
Citations
748
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0
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Recent Articles
1.
Swart L, Fens M, van Oort A, Waranecki P, Mata Casimiro L, Tuk D, et al.
Pharmaceutics
. 2023 Jun;
15(6).
PMID: 37376052
Lipid nanoparticles (LNPs) have evolved rapidly as promising delivery systems for oligonucleotides, including siRNAs. However, current clinical LNP formulations show high liver accumulation after systemic administration, which is unfavorable for...
2.
Rodriguez E, Boelaars K, Brown K, Madunic K, van Ee T, Dijk F, et al.
Commun Biol
. 2022 Jan;
5(1):41.
PMID: 35017635
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a 5-year survival rate of only 9%. Despite the fact that changes in glycosylation patterns during tumour progression...
3.
Affandi A, Grabowska J, Olesek K, Lopez Venegas M, Barbaria A, Rodriguez E, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(44):27528-27539.
PMID: 33067394
Priming of CD8 T cells by dendritic cells (DCs) is crucial for the generation of effective antitumor immune responses. Here, we describe a liposomal vaccine carrier that delivers tumor antigens...
4.
Cornelissen L, Blanas A, Zaal A, van der Horst J, Kruijssen L, OToole T, et al.
Front Oncol
. 2020 Oct;
10:1622.
PMID: 33014816
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support...
5.
Cornelissen L, Blanas A, van der Horst J, Kruijssen L, Zaal A, OToole T, et al.
Int J Cancer
. 2018 Dec;
144(9):2290-2302.
PMID: 30578646
Sialylated glycan structures are known for their immunomodulatory capacities and their contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal cancer and the consequences of complete...
6.
Koning J, Konijn T, Lakeman K, OToole T, Kenswil K, Raaijmakers M, et al.
J Immunol
. 2016 Aug;
197(7):2686-94.
PMID: 27574301
During embryogenesis, lymph nodes form through intimate interaction between lymphoid tissue inducer and lymphoid tissue organizer (LTo) cells. Shortly after birth in mice, specialized stromal cell subsets arise that organize...
7.
Lopes Pinheiro M, Kamermans A, Garcia-Vallejo J, van Het Hof B, Wierts L, OToole T, et al.
Elife
. 2016 Jun;
5.
PMID: 27336724
Trafficking of myelin-reactive CD4(+) T-cells across the brain endothelium, an essential step in the pathogenesis of multiple sclerosis (MS), is suggested to be an antigen-specific process, yet which cells provide...
8.
Verbrugge S, Al M, Assaraf Y, Kammerer S, Chandrupatla D, Honeywell R, et al.
Oncotarget
. 2015 Oct;
7(5):5240-57.
PMID: 26496029
Aminopeptidase inhibitors are receiving attention as combination chemotherapeutic agents for the treatment of refractory acute myeloid leukemia. However, the factors determining therapeutic efficacy remain elusive. Here we identified the molecular...
9.
Ruben J, Visser L, Heinhuis K, OToole T, Bontkes H, Westers T, et al.
PLoS One
. 2015 Aug;
10(8):e0135219.
PMID: 26252775
The CD34+ MUTZ-3 acute myeloid leukemia cell line has been used as a dendritic cell (DC) differentiation model. This cell line can be cultured into Langerhans cell (LC) or interstitial...
10.
Lin J, Spaccapelo R, Schwarzer E, Sajid M, Annoura T, Deroost K, et al.
J Exp Med
. 2015 May;
212(6):893-903.
PMID: 25941254
Most studies on malaria-parasite digestion of hemoglobin (Hb) have been performed using P. falciparum maintained in mature erythrocytes, in vitro. In this study, we examine Plasmodium Hb degradation in vivo...