Tom M Conrad
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Explore the profile of Tom M Conrad including associated specialties, affiliations and a list of published articles.
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12
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1548
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Recent Articles
1.
Kotloff K, Shirley D, Creech C, Frey S, Harrison C, Staat M, et al.
Pediatrics
. 2018 Dec;
143(1).
PMID: 30587533
Methods: Between April 2014 and May 2016, infants <24 months old in the NICU at 8 study centers underwent serial screening for nasal SA. Colonized infants who met eligibility criteria...
2.
Blewett E, Sherrod C, Texier J, Conrad T, Dittmer D
Genome Announc
. 2015 Aug;
3(4).
PMID: 26251484
The complete genome sequences of Mandrillus leucophaeus and Papio ursinus cytomegaloviruses were determined. An isolate from a drill monkey, OCOM6-2, and an isolate from a chacma baboon, OCOM4-52, were subjected...
3.
Yong H, Yamamoto N, Takeuchi R, Hsieh Y, Conrad T, Datsenko K, et al.
Genes Genet Syst
. 2014 Jan;
88(4):233-40.
PMID: 24463526
Genetic interaction networks are especially useful for functional assignment of genes and gaining new insights into the systems-level organization of the cell. While studying interactions of nonessential genes can be...
4.
Orth J, Conrad T, Na J, Lerman J, Nam H, Feist A, et al.
Mol Syst Biol
. 2011 Oct;
7:535.
PMID: 21988831
The initial genome-scale reconstruction of the metabolic network of Escherichia coli K-12 MG1655 was assembled in 2000. It has been updated and periodically released since then based on new and...
5.
Conrad T, Lewis N, Palsson B
Mol Syst Biol
. 2011 Jul;
7:509.
PMID: 21734648
Laboratory evolution studies provide fundamental biological insight through direct observation of the evolution process. They not only enable testing of evolutionary theory and principles, but also have applications to metabolic...
6.
Applebee M, Joyce A, Conrad T, Pettigrew D, Palsson B
J Biol Chem
. 2011 May;
286(26):23150-9.
PMID: 21550976
Herein we measure the effect of four adaptive non-synonymous mutations to the glycerol kinase (glpK) gene on catalytic function and regulation, to identify changes that correlate to increased fitness in...
7.
Nam H, Conrad T, Lewis N
Curr Opin Biotechnol
. 2011 Apr;
22(4):595-600.
PMID: 21481583
Evolution results from molecular-level changes in an organism, thereby producing novel phenotypes and, eventually novel species. However, changes in a single gene can lead to significant changes in biomolecular networks...
8.
Genetic basis of growth adaptation of Escherichia coli after deletion of pgi, a major metabolic gene
Charusanti P, Conrad T, Knight E, Venkataraman K, Fong N, Xie B, et al.
PLoS Genet
. 2010 Nov;
6(11):e1001186.
PMID: 21079674
Bacterial survival requires adaptation to different environmental perturbations such as exposure to antibiotics, changes in temperature or oxygen levels, DNA damage, and alternative nutrient sources. During adaptation, bacteria often develop...
9.
Conrad T, Frazier M, Joyce A, Cho B, Knight E, Lewis N, et al.
Proc Natl Acad Sci U S A
. 2010 Nov;
107(47):20500-5.
PMID: 21057108
Specific small deletions within the rpoC gene encoding the β'-subunit of RNA polymerase (RNAP) are found repeatedly after adaptation of Escherichia coli K-12 MG1655 to growth in minimal media. Here...
10.
Lewis N, Hixson K, Conrad T, Lerman J, Charusanti P, Polpitiya A, et al.
Mol Syst Biol
. 2010 Jul;
6:390.
PMID: 20664636
After hundreds of generations of adaptive evolution at exponential growth, Escherichia coli grows as predicted using flux balance analysis (FBA) on genome-scale metabolic models (GEMs). However, it is not known...