Tom D Bunney
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Explore the profile of Tom D Bunney including associated specialties, affiliations and a list of published articles.
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45
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2048
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Recent Articles
1.
Bunney T, Kampyli C, Gregory A, Katan M
Adv Biol Regul
. 2024 Sep;
94:101053.
PMID: 39313402
The phospholipase C enzyme PLCγ2 is best characterised in the context of immune cell regulation. Furthermore, many mutations discovered in PLCγ2 have been linked to the development of complex immune...
2.
Gong G, Bilanges B, Allsop B, Masson G, Roberton V, Askwith T, et al.
Nature
. 2023 May;
618(7963):159-168.
PMID: 37225977
Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug development. This also applies to the PI3K signalling pathway,...
3.
4.
Prawiro C, Bunney T, Kampyli C, Yaguchi H, Katan M, Bangham C
Biochim Biophys Acta Mol Basis Dis
. 2022 Nov;
1869(2):166601.
PMID: 36442790
Background: Development of adult T-cell leukemia/lymphoma (ATL) involves human T-cell leukemia virus type 1 (HTLV-1) infection and accumulation of somatic mutations. The most frequently mutated gene in ATL (36 %...
5.
Le Huray K, Bunney T, Pinotsis N, Kalli A, Katan M
Sci Adv
. 2022 Jun;
8(25):eabp9688.
PMID: 35749497
PLCγ enzymes are autoinhibited in resting cells and form key components of intracellular signaling that are also linked to disease development. Insights into physiological and aberrant activation of PLCγ require...
6.
Magno L, Bunney T, Mead E, Svensson F, Bictash M
Mol Neurodegener
. 2021 Apr;
16(1):22.
PMID: 33823896
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and...
7.
Martin-Nalda A, Fortuny C, Rey L, Bunney T, Alsina L, Esteve-Sole A, et al.
J Clin Immunol
. 2020 Jul;
40(7):987-1000.
PMID: 32671674
Autoinflammatory diseases (AIDs) were first described as clinical disorders characterized by recurrent episodes of seemingly unprovoked sterile inflammation. In the past few years, the identification of novel AIDs expanded their...
8.
Lima N, Atkinson E, Bunney T, Katan M, Huang P
Int J Mol Sci
. 2020 May;
21(9).
PMID: 32370101
Selective FGFR inhibitors such as infigratinib (BGJ398) and erdafitinib (JNJ-42756493) have been evaluated in clinical trials for cancers with FGFR3 molecular alterations, particularly in urothelial carcinoma patients. However, a substantial...
9.
Liu Y, Bunney T, Khosa S, Mace K, Beckenbauer K, Askwith T, et al.
EBioMedicine
. 2020 Jan;
51:102607.
PMID: 31918402
Background: PLCγ enzymes are key nodes in cellular signal transduction and their mutated and rare variants have been recently implicated in development of a range of diseases with unmet need...
10.
Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR
Koss H, Bunney T, Esposito D, Martins M, Katan M, Driscoll P
Biophys J
. 2018 Jul;
115(1):31-45.
PMID: 29972810
Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second-messenger signaling protein activated by tyrosine kinases such as fibroblast growth factor receptor 1. PLCγ contains the regulatory γ-specific array (γSA) comprising...