Targeting G-CSF to Treat Autoinflammation

Overview

Journal Nat Immunol

Date 2023 Mar 30

PMID 36997672

Authors

Tom D Bunney

Matilda Katan

Affiliations

Soon will be listed here.

Citing Articles

Neutrophil diversity and function in health and disease.

Zhang F, Xia Y, Su J, Quan F, Zhou H, Li Q Signal Transduct Target Ther. 2024; 9(1):343.

PMID: 39638788 PMC: 11627463. DOI: 10.1038/s41392-024-02049-y.

References

McDermott M, Aksentijevich I, Galon J, McDermott E, Ogunkolade B, Centola M . Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell. 1999; 97(1):133-44. DOI: 10.1016/s0092-8674(00)80721-7. View

Aksentijevich I, Schnappauf O . Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases. Nat Rev Rheumatol. 2021; 17(7):405-425. DOI: 10.1038/s41584-021-00614-1. View

Brydges S, Mueller J, McGeough M, Pena C, Misaghi A, Gandhi C . Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity. 2009; 30(6):875-87. PMC: 2759865. DOI: 10.1016/j.immuni.2009.05.005. View

Zhou Q, Lee G, Brady J, Datta S, Katan M, Sheikh A . A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency. Am J Hum Genet. 2012; 91(4):713-20. PMC: 3484656. DOI: 10.1016/j.ajhg.2012.08.006. View

Katan M, Cockcroft S . Phospholipase C families: Common themes and versatility in physiology and pathology. Prog Lipid Res. 2020; 80:101065. DOI: 10.1016/j.plipres.2020.101065. View

Yu P, Constien R, Dear N, Katan M, Hanke P, Bunney T . Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity. 2005; 22(4):451-65. DOI: 10.1016/j.immuni.2005.01.018. View

Ombrello M, Remmers E, Sun G, Freeman A, Datta S, Torabi-Parizi P . Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med. 2012; 366(4):330-8. PMC: 3298368. DOI: 10.1056/NEJMoa1102140. View

Liu Y, Bunney T, Khosa S, Mace K, Beckenbauer K, Askwith T . Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes. EBioMedicine. 2020; 51:102607. PMC: 7000336. DOI: 10.1016/j.ebiom.2019.102607. View

Chae J, Park Y, Park C, Hwang I, Hoffmann P, Kehrl J . Connecting two pathways through Ca 2+ signaling: NLRP3 inflammasome activation induced by a hypermorphic PLCG2 mutation. Arthritis Rheumatol. 2014; 67(2):563-7. PMC: 4369162. DOI: 10.1002/art.38961. View

10.

Martin-Nalda A, Fortuny C, Rey L, Bunney T, Alsina L, Esteve-Sole A . Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations. J Clin Immunol. 2020; 40(7):987-1000. PMC: 7505877. DOI: 10.1007/s10875-020-00794-7. View

11.

Metcalf D . The colony-stimulating factors and cancer. Nat Rev Cancer. 2010; 10(6):425-34. PMC: 3345291. DOI: 10.1038/nrc2843. View