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Todd V Brennan

Explore the profile of Todd V Brennan including associated specialties, affiliations and a list of published articles. Areas
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Articles 56
Citations 791
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Recent Articles
1.
Liang J, Li P, Norman J, Lauzon M, Yeo Y, Trivedi H, et al.
Hepatol Commun . 2024 Jun; 8(7). PMID: 38896084
Background: Serum AFP-L3%, AFP, and DCP are useful biomarkers for HCC detection, but their utility in assessing treatment response remains unknown. We aim to evaluate the accuracy of a biomarker...
2.
Huang Y, Zou Y, Jiao Y, Shi P, Nie X, Huang W, et al.
Front Immunol . 2022 Mar; 13:751296. PMID: 35296079
Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter. It is generally thought that glycolysis, which promotes T cell growth...
3.
Steggerda J, Borja-Cacho D, Brennan T, Todo T, Nissen N, Bloom M, et al.
Transplant Direct . 2022 Jan; 8(2):e1280. PMID: 35047662
Background: Donor liver biopsy (DLBx) in liver transplantation provides information on allograft quality; however, predicting outcomes from these allografts remains difficult. Methods: Between 2006 and 2015, 16 691 transplants with...
4.
Parsons R, Baquerizo A, Kirchner V, Malek S, Desai C, Schenk A, et al.
Am J Transplant . 2021 Jul; 21(10):3225-3238. PMID: 34212485
Although cellular transplantation remains a relatively small field compared to solid organ transplantation, the prospects for advancement in basic science and clinical care remain bountiful. In this review, notable historical...
5.
Halpern S, Rush C, Edwards R, Brennan T, Barbas A, Pollara J
Exp Clin Transplant . 2021 Apr; 19(7):635-644. PMID: 33877036
Objectives: Complement activation in organs from deceased donors is associated with allograft injury and acute rejection. Because use of organs from donors after circulatory death is increasing, we characterized relative...
6.
Zeng F, Chen Z, Chen R, Shufesky W, Bandyopadhyay M, Camirand G, et al.
Sci Transl Med . 2021 Mar; 13(585). PMID: 33731430
Despite the role of donor-specific antibodies (DSAs) in recognizing major histocompatibility complex (MHC) antigens and mediating transplant rejection, how and where recipient B cells in lymphoid tissues encounter donor MHC...
7.
Noureddin N, Yang J, Alkhouri N, Noreen S, Toll A, Todo T, et al.
Transplant Direct . 2020 Nov; 6(11):e612. PMID: 33134488
Background: Changing opinions on the alcohol abstinence requirement have led to increased liver transplantation (LT) for alcoholic hepatitis (AH). We aimed to determine the trend in LT for AH in...
8.
Yang J, Luu M, Singal A, Noureddin M, Kuo A, Ayoub W, et al.
J Natl Compr Canc Netw . 2020 Sep; 18(9):1210-1220. PMID: 32886898
Background: It remains unknown to what extent hepatocellular carcinomas (HCCs) are detected very early (T1 stage; ie, unifocal <2 cm) in the United States. The aim of this study was...
9.
Rendell V, Bath N, Brennan T
OBM Transplant . 2020 Jun; 4(1). PMID: 32582882
Brazilian-born British biologist Dr. Peter Medawar played an integral role in developing the concepts of immunologic rejection and tolerance, which led to him receiving the Nobel Prize "for the discovery...
10.
Bendersky V, Yang Y, Brennan T
Adv Exp Med Biol . 2020 Apr; 1221:461-470. PMID: 32274722
Heparanase regulates multiple biological activities that enhance tumor growth and metastatic spread. Heparanase cleaves and degrades heparan sulfate (HS), a key structural component of the extracellular matrix that serves as...