Todd I Strochlic
Overview
Explore the profile of Todd I Strochlic including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
428
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0
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Recent Articles
1.
Ruiz-Whalen D, Aichele C, Dyson E, Gallen K, Stark J, Saunders J, et al.
Methods Mol Biol
. 2023 Jan;
2626:399-444.
PMID: 36715918
Citizen science is a productive approach to include non-scientists in research efforts that impact particular issues or communities. In most cases, scientists at advanced career stages design high-quality, exciting projects...
2.
Chojnowski J, Li R, Tsang T, Alfaran F, Dick A, Cocklin S, et al.
Front Mol Biosci
. 2022 Jun;
9:878652.
PMID: 35755824
Casein kinase 2 (CK2) is an evolutionarily conserved serine/threonine kinase implicated in a wide range of cellular functions and known to be dysregulated in various diseases such as cancer. Compared...
3.
Williams P, Kobilnyk H, McMillan E, Strochlic T
Cell Stress Chaperones
. 2019 Oct;
24(6):1127-1136.
PMID: 31642047
Developing male germ cells are extremely sensitive to heat stress; consequently, anatomic and physiologic adaptations have evolved to maintain proper thermoregulation during mammalian spermatogenesis. At the cellular level, increased expression...
4.
Chojnowski J, McMillan E, Strochlic T
J Vis Exp
. 2019 Mar;
(144).
PMID: 30855574
The study of kinase-substrate relationships is essential to gain a complete understanding of the functions of these enzymes and their downstream targets in both physiological and pathological states. CK2 is...
5.
McMillan E, Longo S, Smith M, Broskin S, Lin B, Singh N, et al.
J Biol Chem
. 2018 Jan;
293(8):2990-3002.
PMID: 29326167
Lipid metabolism plays a critical role in female reproduction. During oogenesis, maturing oocytes accumulate high levels of neutral lipids that are essential for both energy production and the synthesis of...
6.
Williams P, Krug M, McMillan E, Peake J, Davis T, Cocklin S, et al.
Mol Biol Cell
. 2016 Jun;
27(15):2341-50.
PMID: 27280388
Developing male germ cells are exquisitely sensitive to environmental insults such as heat and oxidative stress. An additional characteristic of these cells is their unique dependence on RNA-binding proteins for...
7.
Strochlic T, Stavrides K, Thomas S, Nicolas E, OReilly A, Peterson J
EMBO Rep
. 2014 Sep;
15(11):1184-91.
PMID: 25223282
The enzyme CTP synthase (CTPS) dynamically assembles into macromolecular filaments in bacteria, yeast, Drosophila, and mammalian cells, but the role of this morphological reorganization in regulating CTPS activity is controversial....
8.
Hartman T, Strochlic T, Ji Y, Zinshteyn D, OReilly A
J Cell Biol
. 2013 May;
201(5):741-57.
PMID: 23690177
A healthy diet improves adult stem cell function and delays diseases such as cancer, heart disease, and neurodegeneration. Defining molecular mechanisms by which nutrients dictate stem cell behavior is a...
9.
Strochlic T, Concilio S, Viaud J, Eberwine R, Wong L, Minden A, et al.
Proc Natl Acad Sci U S A
. 2012 Feb;
109(11):4116-21.
PMID: 22371566
Synaptic transmission is mediated by a complex set of molecular events that must be coordinated in time and space. While many proteins that function at the synapse have been identified,...
10.
Strochlic T, Viaud J, Rennefahrt U, Anastassiadis T, Peterson J
Mol Cell
. 2010 Nov;
40(3):493-500.
PMID: 21070974
Phospholipid-enriched membranes such as the plasma membrane can serve as direct regulators of kinase signaling. Pak1 is involved in growth factor signaling at the plasma membrane, and its dysregulation is...