Christopher G Burd
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Explore the profile of Christopher G Burd including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Kim Y, Parolek J, Burd C
bioRxiv
. 2025 Feb;
PMID: 39990424
Summary: In cellular membranes, sphingomyelin is associated with cholesterol. Metabolic flux analysis of sphingolipid metabolism showed that synthesis rate of sphingomyelin, but not ceramide, was increased after depletion of cholesterol...
2.
Parolek J, Burd C
Mol Biol Cell
. 2024 Mar;
35(5):br11.
PMID: 38536441
Bridge-like lipid transfer protein family member 2 (BLTP2) is an evolutionary conserved protein with unknown function(s). The absence of BLTP2 in results in impaired cellular secretion and larval death, while...
3.
Kim Y, Mavodza G, Senkal C, Burd C
J Cell Biol
. 2023 Oct;
222(12).
PMID: 37787764
Sphingomyelin plays a key role in cellular cholesterol homeostasis by binding to and sequestering cholesterol in the plasma membrane. We discovered that synthesis of very long chain (VLC) sphingomyelins is...
4.
Kim Y, Burd C
Cold Spring Harb Perspect Biol
. 2023 Jul;
15(10).
PMID: 37487627
The sorting and trafficking of lipids between organelles gives rise to a dichotomy of bulk membrane properties between organelles of the secretory and endolysosome networks, giving rise to two "membrane...
5.
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
Sokoya T, Parolek J, Foged M, Danylchuk D, Bozan M, Sarkar B, et al.
Elife
. 2022 Sep;
11.
PMID: 36102623
Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway....
6.
Ford C, Burd C
Mol Biol Cell
. 2022 Jul;
33(10):ar86.
PMID: 35830596
The -Golgi network must coordinate sorting and secretion of proteins and lipids to intracellular organelles and the plasma membrane. During polarization of epithelial cells, changes in the lipidome and the...
7.
Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, et al.
Nat Commun
. 2022 Apr;
13(1):1875.
PMID: 35388011
Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell viability. Here we report that cells exploit a...
8.
Ford C, Parchure A, von Blume J, Burd C
J Cell Sci
. 2021 Dec;
134(23).
PMID: 34870705
The Golgi functions principally in the biogenesis and trafficking of glycoproteins and lipids. It is compartmentalized into multiple flattened adherent membrane sacs termed cisternae, which each contain a distinct repertoire...
9.
Burd C
J Cell Biol
. 2021 Apr;
220(5).
PMID: 33848329
Cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon. Two proteins, GRASP65 and GRASP55, previously implicated...
10.
Kumar S, Chitraju C, Farese Jr R, Walther T, Burd C
Biol Open
. 2021 Feb;
10(3).
PMID: 33593792
Phosphatidylethanolamine is an abundant component of most cellular membranes whose physical and chemical properties modulate multiple aspects of organelle membrane dynamics. An evolutionarily ancient mechanism for producing phosphatidylethanolamine is to...