Todd Black
Overview
Explore the profile of Todd Black including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
250
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0
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Recent Articles
1.
Komm O, Tyagi S, Garcia A, Almeida D, Chang Y, Li S, et al.
Antimicrob Agents Chemother
. 2024 Dec;
69(1):e0096224.
PMID: 39651910
The clinical efficacy of combination drug regimens containing the first-generation diarylquinoline (DARQ) bedaquiline in the treatment of multidrug-resistant tuberculosis has validated ATP synthesis as a vulnerable pathway in . New...
2.
Dong S, Zhao Z, Tang H, Li G, Pan J, Gu X, et al.
J Med Chem
. 2024 Feb;
67(5):3400-3418.
PMID: 38387069
The use of β-lactam (BL) and β-lactamase inhibitor combination to overcome BL antibiotic resistance has been validated through clinically approved drug products. However, unmet medical needs still exist for the...
3.
Mandal M, Xiao L, Pan W, Scapin G, Li G, Tang H, et al.
J Med Chem
. 2022 Dec;
65(24):16234-16251.
PMID: 36475645
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial...
4.
Lahser F, Galloway A, Hwang P, Palcza J, Brunhofer J, Wahl J, et al.
Antivir Ther
. 2018 Jul;
23(7):593-603.
PMID: 30038064
Background: In HCV-infected people who fail to achieve sustained virological response after receiving a direct-acting antiviral regimen, virological failure is almost always accompanied by the presence of resistance-associated substitutions (RASs)...
5.
Warn P, Thommes P, Sattar A, Corbett D, Flattery A, Zhang Z, et al.
Antimicrob Agents Chemother
. 2016 Aug;
60(11):6471-6482.
PMID: 27527088
Clostridium difficile causes infections of the colon in susceptible patients. Specifically, gut dysbiosis induced by treatment with broad-spectrum antibiotics facilitates germination of ingested C. difficile spores, expansion of vegetative cells,...
6.
Lahser F, Bystol K, Curry S, McMonagle P, Xia E, Ingravallo P, et al.
Antimicrob Agents Chemother
. 2016 Mar;
60(5):2954-64.
PMID: 26926625
The selection of resistance-associated variants (RAVs) against single agents administered to patients chronically infected with hepatitis C virus (HCV) necessitates that direct-acting antiviral agents (DAAs) targeting multiple viral proteins be...
7.
Singh S, Kaelin D, Wu J, Miesel L, Tan C, Gill C, et al.
Bioorg Med Chem Lett
. 2015 May;
25(12):2473-8.
PMID: 25978963
Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of broad-spectrum antibacterial agents targeting bacterial Gyrase A and ParC and have potential utility in combating antibiotic resistance. (R)-Hydroxy-1,5-naphthyridinone left-hand side...
8.
Singh S, Kaelin D, Wu J, Miesel L, Tan C, Black T, et al.
Bioorg Med Chem Lett
. 2015 Apr;
25(9):1831-5.
PMID: 25851938
Novel bacterial topoisomerase inhibitors (NBTIs) represent a new class of broad-spectrum antibacterial agents targeting bacterial Gyrase A and ParC and have potential utility in combating antibiotic resistance. A series of...
9.
Mann P, Muller A, Xiao L, Pereira P, Yang C, Lee S, et al.
ACS Chem Biol
. 2013 Aug;
8(11):2442-51.
PMID: 23957438
Modern medicine is founded on the discovery of penicillin and subsequent small molecules that inhibit bacterial peptidoglycan (PG) and cell wall synthesis. However, the discovery of new chemically and mechanistically...
10.
Wang H, Gill C, Lee S, Mann P, Zuck P, Meredith T, et al.
Chem Biol
. 2013 Feb;
20(2):272-84.
PMID: 23438756
Innovative strategies are needed to combat drug resistance associated with methicillin-resistant Staphylococcus aureus (MRSA). Here, we investigate the potential of wall teichoic acid (WTA) biosynthesis inhibitors as combination agents to...