Toby W Allen
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Explore the profile of Toby W Allen including associated specialties, affiliations and a list of published articles.
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52
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1810
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Recent Articles
1.
Lev B, Vorobyov I, Clarke R, Allen T
J Phys Chem B
. 2024 Sep;
128(39):9482-9499.
PMID: 39303305
Understanding membrane charge transport processes, including the actions of ion channels, pumps, carriers, and membrane-active peptides, requires a description of the electrostatics of the lipid bilayer. We have simulated a...
2.
Lau C, Flood E, Hunter M, Williams-Noonan B, Corbett K, Ng C, et al.
Nat Commun
. 2024 Aug;
15(1):7470.
PMID: 39209832
The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go...
3.
Fan C, Flood E, Sukomon N, Agarwal S, Allen T, Nimigean C
Nat Chem Biol
. 2023 Aug;
20(1):52-61.
PMID: 37653172
Quaternary ammonium blockers were previously shown to bind in the pore to block both open and closed conformations of large-conductance calcium-activated potassium (BK and MthK) channels. Because blocker entry was...
4.
NGo V, Li H, MacKerell Jr A, Allen T, Roux B, Noskov S
J Chem Theory Comput
. 2021 Feb;
17(3):1726-1741.
PMID: 33539082
Despite the progress in modeling complex molecular systems of ever-increasing complexity, a quantitatively accurate computational treatment of ion permeation through narrow membrane channels remains challenging. An important factor to reach...
5.
Chen P, Vorobyov I, Roux B, Allen T
J Phys Chem B
. 2021 Jan;
125(4):1020-1035.
PMID: 33493394
Different mechanisms have been proposed to explain the permeation of charged compounds through lipid membranes. Overall, it is expected that an ion-induced defect permeation mechanism, where substantial membrane deformations accompany...
6.
Boiteux C, Posson D, Allen T, Nimigean C
Proc Natl Acad Sci U S A
. 2020 Nov;
117(47):29968-29978.
PMID: 33154158
Potassium channels can become nonconducting via inactivation at a gate inside the highly conserved selectivity filter (SF) region near the extracellular side of the membrane. In certain ligand-gated channels, such...
7.
Fan C, Sukomon N, Flood E, Rheinberger J, Allen T, Nimigean C
Nature
. 2020 Apr;
580(7802):288-293.
PMID: 32269335
Inactivation is the process by which ion channels terminate ion flux through their pores while the opening stimulus is still present. In neurons, inactivation of both sodium and potassium channels...
8.
Lynagh T, Flood E, Boiteux C, Sheikh Z, Allen T, Pless S
J Gen Physiol
. 2020 Jan;
152(2).
PMID: 31952079
Trimeric acid-sensing ion channels (ASICs) contribute to neuronal signaling by converting extracellular acidification into excitatory sodium currents. Previous work with homomeric ASIC1a implicates conserved leucine (L7') and consecutive glycine-alanine-serine (GAS...
9.
Lev B, Allen T
J Comput Chem
. 2019 Nov;
41(5):387-401.
PMID: 31743478
Atomic-level studies of protein activity represent a significant challenge as a result of the complexity of conformational changes occurring on wide-ranging timescales, often greatly exceeding that of even the longest...
10.
Flood E, Boiteux C, Lev B, Vorobyov I, Allen T
Chem Rev
. 2019 Jun;
119(13):7737-7832.
PMID: 31246417
Membrane ion channels are the fundamental electrical components in the nervous system. Recent developments in X-ray crystallography and cryo-EM microscopy have revealed what these proteins look like in atomic detail...