Igor Vorobyov
Overview
Explore the profile of Igor Vorobyov including associated specialties, affiliations and a list of published articles.
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40
Citations
2948
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Recent Articles
1.
Nasburg J, Rouen K, Dietrich C, Shim H, Zhang M, Vorobyov I, et al.
Mol Pharmacol
. 2025 Mar;
107(3):100018.
PMID: 40068526
NS309 (6,7-dichloro-1H-indole-2,3-dione-3-oxime) is widely used as a pharmacological tool to increase the activity of small- and intermediate-conductance calcium-activated potassium channels. NS309 is assumed to function as a positive allosteric gating...
2.
Han Y, Dawson J, DeMarco K, Rouen K, Ngo K, Bekker S, et al.
iScience
. 2025 Feb;
28(2):111741.
PMID: 39898043
G protein-coupled receptors (GPCRs) and G proteins transmit signals from hormones and neurotransmitters across cell membranes, initiating downstream signaling and modulating cellular behavior. Using advanced computer modeling and simulation, we...
3.
Fiore C, Quigley K, Vorobyov I, Clancy C, Harvey R
JACC Clin Electrophysiol
. 2025 Feb;
PMID: 39895450
Background: hERG encodes K11.1 voltage-gated K channels, which generate the rapidly activating delayed rectifier K current that contributes to repolarization of the cardiac action potential. In addition to being targeted...
4.
Lev B, Vorobyov I, Clarke R, Allen T
J Phys Chem B
. 2024 Sep;
128(39):9482-9499.
PMID: 39303305
Understanding membrane charge transport processes, including the actions of ion channels, pumps, carriers, and membrane-active peptides, requires a description of the electrostatics of the lipid bilayer. We have simulated a...
5.
Woltz R, Zheng Y, Choi W, Ngo K, Trinh P, Ren L, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(39):e2318900121.
PMID: 39288178
Small-conductance Ca-activated K channels (SK, K2) are gated solely by intracellular microdomain Ca. The channel has emerged as a therapeutic target for cardiac arrhythmias. Calmodulin (CaM) interacts with the CaM...
6.
Ngo K, Yang P, Yarov-Yarovoy V, Clancy C, Vorobyov I
bioRxiv
. 2024 Feb;
PMID: 38352360
To design safe, selective, and effective new therapies, there must be a deep understanding of the structure and function of the drug target. One of the most difficult problems to...
7.
Ngo K, Mateos D, Han Y, Rouen K, Ahn S, Wulff H, et al.
J Gen Physiol
. 2023 Dec;
156(2).
PMID: 38127314
Human voltage-gated sodium (hNaV) channels are responsible for initiating and propagating action potentials in excitable cells, and mutations have been associated with numerous cardiac and neurological disorders. hNaV1.7 channels are...
8.
Yang P, Jeng M, Yarov-Yarovoy V, Santana L, Vorobyov I, Clancy C
JACC Clin Electrophysiol
. 2023 Dec;
10(2):359-364.
PMID: 38069976
The authors demonstrate the feasibility of technological innovation for personalized medicine in the context of drug-induced arrhythmia. The authors use atomistic-scale structural models to predict rates of drug interaction with...
9.
Emigh Cortez A, DeMarco K, Furutani K, Bekker S, Sack J, Wulff H, et al.
Front Pharmacol
. 2023 Nov;
14:1244166.
PMID: 38035013
The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target. Genetic hERG...
10.
Yang P, Rose A, DeMarco K, Dawson J, Han Y, Jeng M, et al.
J Physiol
. 2023 Aug;
601(17):3789-3812.
PMID: 37528537
Cardiac function is tightly regulated by the autonomic nervous system (ANS). Activation of the sympathetic nervous system increases cardiac output by increasing heart rate and stroke volume, while parasympathetic nerve...