Tobias Karlberg
Overview
Explore the profile of Tobias Karlberg including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
1821
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0
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Recent Articles
1.
Saei A, Beusch C, Sabatier P, Wells J, Gharibi H, Meng Z, et al.
Nat Commun
. 2021 Feb;
12(1):1296.
PMID: 33637753
Despite the immense importance of enzyme-substrate reactions, there is a lack of general and unbiased tools for identifying and prioritizing substrate proteins that are modified by the enzyme on the...
2.
Nowak K, Rosenthal F, Karlberg T, Butepage M, Thorsell A, Dreier B, et al.
Nat Commun
. 2020 Oct;
11(1):5199.
PMID: 33060572
Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis...
3.
Thorsell A, Ekblad T, Karlberg T, Low M, Pinto A, Tresaugues L, et al.
J Med Chem
. 2019 Jun;
62(12):5922.
PMID: 31242737
No abstract available.
4.
Kirby I, Kojic A, Arnold M, Thorsell A, Karlberg T, Vermehren-Schmaedick A, et al.
Cell Chem Biol
. 2018 Oct;
25(12):1547-1553.e12.
PMID: 30344052
Poly-ADP-ribose polymerases (PARPs1-16) play pivotal roles in diverse cellular processes. PARPs that catalyze poly-ADP-ribosylation (PARylation) are the best characterized PARP family members because of the availability of potent and selective ...
5.
Karlberg T, Hornyak P, Pinto A, Milanova S, Ebrahimi M, Lindberg M, et al.
Nat Commun
. 2018 Sep;
9(1):3785.
PMID: 30224724
Pseudomonas are a common cause of hospital-acquired infections that may be lethal. ADP-ribosyltransferase activities of Pseudomonas exotoxin-S and -T depend on 14-3-3 proteins inside the host cell. By binding in...
6.
Holechek J, Lease R, Thorsell A, Karlberg T, McCadden C, Grant R, et al.
Bioorg Med Chem Lett
. 2018 May;
28(11):2050-2054.
PMID: 29748053
A series of diaryl ethers were designed and synthesized to discern the structure activity relationships against the two closely related mono-(ADP-ribosyl)transferases PARP10 and PARP14. Structure activity studies identified 8b as...
7.
Upton K, Meyers M, Thorsell A, Karlberg T, Holechek J, Lease R, et al.
Bioorg Med Chem Lett
. 2017 May;
27(13):2907-2911.
PMID: 28495083
A series of (Z)-4-(3-carbamoylphenylamino)-4-oxobut-2-enyl amides were synthesized and tested for their ability to inhibit the mono-(ADP-ribosyl)transferase, PARP14 (a.k.a. BAL-2; ARTD-8). Two synthetic routes were established for this series and several...
8.
Thorsell A, Ekblad T, Karlberg T, Low M, Pinto A, Tresaugues L, et al.
J Med Chem
. 2016 Dec;
60(4):1262-1271.
PMID: 28001384
Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 clinical PARP inhibitors and commonly used research...
9.
Peng B, Thorsell A, Karlberg T, Schuler H, Yao S
Angew Chem Int Ed Engl
. 2016 Dec;
56(1):248-253.
PMID: 27918638
Poly(ADP-ribose) polymerases (PARPs) are key enzymes in a variety of cellular processes. Most small-molecule PARP inhibitors developed to date have been against PARP1, and suffer from poor selectivity. PARP14 has...
10.
Kouznetsova E, Kanno T, Karlberg T, Thorsell A, Wisniewska M, Kursula P, et al.
Structure
. 2016 Apr;
24(5):789-796.
PMID: 27112597
Sister chromatid cohesion, formed by the cohesin protein complex, is essential for chromosome segregation. In order for cohesion to be established, the cohesin subunit SMC3 needs to be acetylated by...