Tobias Eilert
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Explore the profile of Tobias Eilert including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
240
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Recent Articles
1.
Schach S, Eilert T, Presser B, Kunzelmann M
Bioengineering (Basel)
. 2025 Feb;
12(2).
PMID: 40001712
Determining process variances in biopharmaceutical manufacturing is challenging due to limited data availability. To address this, we introduce a Bayesian hierarchical model designed for meta-analysis of process variance. This approach...
2.
Cordero M, Meinfelder F, Eilert T
J Pharm Sci
. 2024 Feb;
113(7):1779-1793.
PMID: 38417792
In preparation to the launch of a pharmaceutical product, an estimate of its shelf life via stability testing is required by regulatory agencies. The ICH-Q1E guidance has been the worldwide...
3.
Sefer A, Kallis E, Eilert T, Rocker C, Kolesnikova O, Neuhaus D, et al.
Nat Commun
. 2022 Nov;
13(1):6569.
PMID: 36323657
Single-stranded breaks (SSBs) are the most frequent DNA lesions threatening genomic integrity. A highly kinked DNA structure in complex with human PARP-1 domains led to the proposal that SSB sensing...
4.
Weggler T, Ganslmayer C, Frank F, Eilert T, Jelezko F, Michaelis J
Nano Lett
. 2020 Mar;
20(5):2980-2985.
PMID: 32182080
Absolute knowledge about the magnetic field orientation plays a crucial role in single spin-based quantum magnetometry and the application toward spin-based quantum computation. In this paper, we reconstruct the three-dimensional...
5.
Eilert T, Kallis E, Nagy J, Rocker C, Michaelis J
J Phys Chem B
. 2018 Oct;
122(49):11677-11694.
PMID: 30351105
Förster resonance energy transfer (FRET) can be used to measure distances and infer structures at the molecular level. However, the flexible linkers with which the fluorophores are attached to a...
6.
Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kuhnemuth R, Rezaei Adariani S, et al.
Nat Methods
. 2018 Oct;
15(11):984.
PMID: 30327572
This paper was originally published under standard Springer Nature copyright. As of the date of this correction, the Analysis is available online as an open-access paper with a CC-BY license....
7.
Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kuhnemuth R, Rezaei Adariani S, et al.
Nat Methods
. 2018 Sep;
15(9):669-676.
PMID: 30171252
Single-molecule Förster resonance energy transfer (smFRET) is increasingly being used to determine distances, structures, and dynamics of biomolecules in vitro and in vivo. However, generalized protocols and FRET standards to...
8.
Nagy J, Eilert T, Michaelis J
J Chem Phys
. 2018 Apr;
148(12):123308.
PMID: 29604844
Modern hybrid structural analysis methods have opened new possibilities to analyze and resolve flexible protein complexes where conventional crystallographic methods have reached their limits. Here, the Fast-Nano-Positioning System (Fast-NPS), a...
9.
Malkusch N, Dorfler T, Nagy J, Eilert T, Michaelis J
Methods
. 2017 Apr;
120:115-124.
PMID: 28434999
Single-molecule fluorescence and in particular single-molecule Förster Resonance Energy Transfer (smFRET) is a powerful tool to provide real-time information on the dynamic architecture of large macromolecular structures such as eukaryotic...
10.
Dorfler T, Eilert T, Rocker C, Nagy J, Michaelis J
J Vis Exp
. 2017 Mar;
(120).
PMID: 28287526
Single-molecule Förster Resonance Energy Transfer (smFRET) can be used to obtain structural information on biomolecular complexes in real-time. Thereby, multiple smFRET measurements are used to localize an unknown dye position...