Jens Michaelis
Overview
Explore the profile of Jens Michaelis including associated specialties, affiliations and a list of published articles.
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Articles
75
Citations
1687
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Recent Articles
1.
Lietz S, Sommer A, Sokolowski L, Kling C, Rodriguez Alfonso A, Preising N, et al.
J Biol Chem
. 2024 Oct;
300(12):107950.
PMID: 39481600
Pertussis (whooping cough) is a vaccine-preventable but re-emerging, highly infectious respiratory disease caused by Bordetella pertussis. There are currently no effective treatments for pertussis, complicating care for nonvaccinated individuals, especially...
2.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, et al.
Nat Commun
. 2023 Nov;
14(1):6770.
PMID: 37914730
Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the endoplasmic reticulum (ER)-Golgi axis to...
3.
Heber S, Borho J, Stadler N, Wondany F, Konig I, Michaelis J, et al.
Toxins (Basel)
. 2023 Jun;
15(6).
PMID: 37368691
The binary () C2 toxin consists of two non-linked proteins. The proteolytically activated binding/transport subunit C2IIa forms barrel-shaped homoheptamers, which bind to cell surface receptors, mediate endocytosis, and translocate the...
4.
Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model
Heuvel F, Alami N, Aousji O, Pogatzki-Zahn E, Zahn P, Wilhelm H, et al.
Mol Autism
. 2023 Jun;
14(1):21.
PMID: 37316943
Background: Autism Spectrum Disorders (ASD) patients experience disturbed nociception in the form of either hyposensitivity to pain or allodynia. A substantial amount of processing of somatosensory and nociceptive stimulus takes...
5.
Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, et al.
BMC Biol
. 2023 May;
21(1):113.
PMID: 37221592
Background: Post mortem human brain tissue is an essential resource to study cell types, connectivity as well as subcellular structures down to the molecular setup of the central nervous system...
6.
Agam G, Gebhardt C, Popara M, Machtel R, Folz J, Ambrose B, et al.
Nat Methods
. 2023 Mar;
20(4):523-535.
PMID: 36973549
Single-molecule Förster-resonance energy transfer (smFRET) experiments allow the study of biomolecular structure and dynamics in vitro and in vivo. We performed an international blind study involving 19 laboratories to assess...
7.
Sefer A, Kallis E, Eilert T, Rocker C, Kolesnikova O, Neuhaus D, et al.
Nat Commun
. 2022 Nov;
13(1):6569.
PMID: 36323657
Single-stranded breaks (SSBs) are the most frequent DNA lesions threatening genomic integrity. A highly kinked DNA structure in complex with human PARP-1 domains led to the proposal that SSB sensing...
8.
Fellermann M, Stemmer M, Noschka R, Wondany F, Fischer S, Michaelis J, et al.
Toxins (Basel)
. 2022 Oct;
14(10).
PMID: 36287979
The protein toxin C3bot from is a mono-ADP-ribosyltransferase that selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and dendritic cells (DCs) by cytosolic modification of Rho-A, -B, and -C. Here,...
9.
Streit L, Kuhn T, Vomhof T, Bopp V, Ludolph A, Weishaupt J, et al.
Nat Commun
. 2022 Sep;
13(1):5480.
PMID: 36123343
TAR DNA binding protein 43 (TDP-43) is closely related to the pathogenesis of amyotrophic lateral sclerosis (ALS) and translocates to stress granules (SGs). The role of SGs as aggregation-promoting "crucibles"...
10.
Kuchler O, Gerlach J, Vomhof T, Hettich J, Steinmetz J, Gebhardt J, et al.
Open Biol
. 2022 May;
12(5):210383.
PMID: 35537478
In cells, proteins encoded by the same gene do not all behave uniformly but engage in functional subpopulations induced by spatial or temporal segregation. While conventional microscopy has limitations in...