Tingjian Chen
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Explore the profile of Tingjian Chen including associated specialties, affiliations and a list of published articles.
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31
Citations
481
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Recent Articles
21.
Chen T, Hongdilokkul N, Liu Z, Thirunavukarasu D, Romesberg F
Curr Opin Chem Biol
. 2016 Aug;
34:80-87.
PMID: 27565457
DNA and RNA are remarkable because they can both encode information and possess desired properties, including the ability to bind specific targets or catalyze specific reactions. Nucleotide modifications that do...
22.
Chen T, Hongdilokkul N, Liu Z, Adhikary R, Tsuen S, Romesberg F
Nat Chem
. 2016 May;
8(6):556-62.
PMID: 27219699
The PCR amplification of oligonucleotides enables the evolution of sequences called aptamers that bind specific targets with antibody-like affinity. However, in many applications the use of these aptamers is limited...
23.
Adhikary R, Yu W, Oda M, Walker R, Chen T, Stanfield R, et al.
Biochemistry
. 2015 Mar;
54(11):2085-93.
PMID: 25756188
While adaptive mutations can bestow new functions on proteins via the introduction or optimization of reactive centers, or other structural changes, a role for the optimization of protein dynamics also...
24.
Malyshev D, Dhami K, Lavergne T, Chen T, Dai N, Foster J, et al.
Nature
. 2014 May;
509(7500):385-8.
PMID: 24805238
Organisms are defined by the information encoded in their genomes, and since the origin of life this information has been encoded using a two-base-pair genetic alphabet (A-T and G-C). In...
25.
Chen T, Romesberg F
FEBS Lett
. 2013 Nov;
588(2):219-29.
PMID: 24211837
Polymerases evolved in nature to synthesize DNA and RNA, and they underlie the storage and flow of genetic information in all cells. The availability of these enzymes for use at...
26.
Serum miR-19a expression correlates with worse prognosis of patients with non-small cell lung cancer
Lin Q, Chen T, Lin Q, Lin G, Lin J, Chen G, et al.
J Surg Oncol
. 2013 Apr;
107(7):767-71.
PMID: 23609137
Objectives: The aim of this study was to investigate the expression levels of miR-19a in non-small cell lung cancer (NSCLC) tissue and serum, and to clarify the relationships of serum...
27.
Chen T, Wang J, Zeng L, Li R, Li J, Chen Y, et al.
PLoS One
. 2012 Jul;
7(7):e37126.
PMID: 22792156
Cell reprogramming for microorganisms via engineered or artificial transcription factors and RNA polymerase mutants has presented a powerful tool for eliciting complex traits that are practically useful particularly for industrial...
28.
Chen T, Wang J, Yang R, Li J, Lin M, Lin Z
PLoS One
. 2011 Jan;
6(1):e16228.
PMID: 21267412
Background: The tolerance of cells toward different stresses is very important for industrial strains of microbes, but difficult to improve by the manipulation of single genes. Traditional methods for enhancing...
29.
Ren C, Chen T, Zhang J, Liang L, Lin Z
Microb Cell Fact
. 2009 Dec;
8:66.
PMID: 20003468
Background: Xylose is a second most abundant sugar component of lignocellulose besides glucose. Efficient fermentation of xylose is important for the economics of biomass-based biorefineries. However, sugar mixtures are sequentially...
30.
Chen T, Zhang J, Liang L, Yang R, Lin Z
Anal Biochem
. 2009 Apr;
390(1):63-7.
PMID: 19351525
Efficient use of xylose is necessary for economic production of biochemicals and biofuels from lignocellulosic materials. Current studies on xylose uptake for various microorganisms have been hampered by the lack...