Floyd E Romesberg
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Explore the profile of Floyd E Romesberg including associated specialties, affiliations and a list of published articles.
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160
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3759
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Recent Articles
1.
Romesberg F
Philos Trans R Soc Lond B Biol Sci
. 2023 Jan;
378(1871):20220030.
PMID: 36633274
Much recent interest has focused on developing proteins for human use, such as in medicine. However, natural proteins are made up of only a limited number of canonical amino acids...
2.
Romesberg F
J Mol Biol
. 2021 Oct;
434(8):167331.
PMID: 34710400
With few exceptions, natural proteins are built from only 20 canonical (proteogenic) amino acids which limits the functionality and accordingly the properties they can possess. Genetic code expansion, i.e. the...
3.
Oh J, Shin J, Unarta I, Wang W, Feldman A, Karadeema R, et al.
Nat Chem Biol
. 2021 Jun;
17(8):906-914.
PMID: 34140682
The development of unnatural base pairs (UBPs) has greatly increased the information storage capacity of DNA, allowing for transcription of unnatural RNA by the heterologously expressed T7 RNA polymerase (RNAP)...
4.
Hashimoto K, Fischer E, Romesberg F
J Am Chem Soc
. 2021 Jun;
143(23):8603-8607.
PMID: 34096294
We have developed semisynthetic organisms (SSOs) that by virtue of a family of synthetic, unnatural base pairs (UBPs), store and retrieve increased information. To date, transcription in the SSOs has...
5.
Manandhar M, Chun E, Romesberg F
J Am Chem Soc
. 2021 Mar;
143(13):4859-4878.
PMID: 33756076
Virtually all natural proteins are built from only 20 amino acids, and while this makes possible all the functions they perform, the ability to encode other amino acids selected for...
6.
Zhou A, Dong X, Romesberg F
J Am Chem Soc
. 2020 Oct;
142(45):19029-19032.
PMID: 33118814
Through the development of unnatural base pairs that are compatible with native DNA and RNA polymerases and the ribosome, we have expanded the genetic alphabet and enabled in vitro and...
7.
Tan Y, Peters D, Walsh S, Holcomb M, Santos-Martins D, Forli S, et al.
J Nat Prod
. 2020 Jul;
83(7):2112-2121.
PMID: 32614583
The arylomycins are a class of natural product antibiotics that inhibit bacterial type I signal peptidase and are under development as therapeutics. Four classes of arylomycins are known, arylomycins A-D....
8.
Fischer E, Hashimoto K, Zhang Y, Feldman A, Dien V, Karadeema R, et al.
Nat Chem Biol
. 2020 Apr;
16(5):570-576.
PMID: 32251411
Natural organisms use a four-letter genetic alphabet that makes available 64 triplet codons, of which 61 are sense codons used to encode proteins with the 20 canonical amino acids. We...
9.
Ledbetter M, Craig J, Karadeema R, Noakes M, Kim H, Abell S, et al.
J Am Chem Soc
. 2020 Jan;
142(5):2110-2114.
PMID: 31985216
Unnatural base pairs (UBPs) have been developed and used for a variety of applications as well as for the engineering of semisynthetic organisms (SSOs) that store and retrieve increased information....
10.
Shao Q, Chen T, Sheng K, Liu Z, Zhang Z, Romesberg F
J Am Chem Soc
. 2020 Jan;
142(5):2125-2128.
PMID: 31961667
Previously, we evolved a DNA polymerase, SFM4-3, for the recognition of substrates modified at their 2' positions with a fluoro, -methyl, or azido substituent. Here we use SFM4-3 to synthesize...