Tingjian Chen
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Explore the profile of Tingjian Chen including associated specialties, affiliations and a list of published articles.
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31
Citations
481
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Recent Articles
11.
Sun L, Ma X, Zhang B, Qin Y, Ma J, Du Y, et al.
RSC Chem Biol
. 2022 Nov;
3(10):1173-1197.
PMID: 36320892
Nucleic acids have been extensively modified in different moieties to expand the scope of genetic materials in the past few decades. While the development of unnatural base pairs (UBPs) has...
12.
Guo Y, Zhang R, Huo B, Wang L, Yuan D, Bai J, et al.
Chem Commun (Camb)
. 2022 Oct;
58(83):11717-11720.
PMID: 36184910
Base excision (BE) is an important yet hard-to-control biological event. Unnatural base pairs are powerful tools to revolutionize biological studies in various areas. In this paper, we report a visible-light-induced...
13.
Zhu G, Song P, Wu J, Luo M, Chen Z, Chen T
Front Bioeng Biotechnol
. 2022 Jan;
9:792489.
PMID: 35071205
Nucleic acids underlie the storage and retrieval of genetic information literally in all living organisms, and also provide us excellent materials for making artificial nanostructures and scaffolds for constructing multi-enzyme...
14.
Song P, Zhang R, He C, Chen T
Curr Protoc
. 2021 Jul;
1(7):e188.
PMID: 34232574
Backbone-modified nucleic acids are usually more stable enzymatically than their natural counterparts, enabling their broad application as potential diagnostic or therapeutic agents. Moreover, the development of nucleic acids with unnatural...
15.
Shao Q, Chen T, Sheng K, Liu Z, Zhang Z, Romesberg F
J Am Chem Soc
. 2020 Jan;
142(5):2125-2128.
PMID: 31961667
Previously, we evolved a DNA polymerase, SFM4-3, for the recognition of substrates modified at their 2' positions with a fluoro, -methyl, or azido substituent. Here we use SFM4-3 to synthesize...
16.
Liu Z, Chen T, Romesberg F
Chem Sci
. 2018 Mar;
8(12):8179-8182.
PMID: 29568464
RNA or DNA aptamers with 2'-OMe-modifications have been pursued to increase resistance to nucleases, but have been difficult to identify because the OMe groups ablate polymerase recognition. We recently reported...
17.
Chen T, Romesberg F
Biochemistry
. 2017 Sep;
56(40):5227-5228.
PMID: 28930440
No abstract available.
18.
Chen T, Romesberg F
Angew Chem Int Ed Engl
. 2017 Sep;
56(45):14046-14051.
PMID: 28914996
The ability to amplify DNA along with its unprecedented sequence control has led to its use for different applications, but all are limited by the properties available to natural nucleotides....
19.
Chen T, Romesberg F
J Am Chem Soc
. 2017 Jul;
139(29):9949-9954.
PMID: 28715205
There is increasing demand for RNA and modified RNA oligonucleotides, but in contrast to DNA oligonucleotides, they are typically prohibitively expensive to chemically synthesize, and unlike longer RNAs, they are...
20.
Thirunavukarasu D, Chen T, Liu Z, Hongdilokkul N, Romesberg F
J Am Chem Soc
. 2017 Feb;
139(8):2892-2895.
PMID: 28218835
RNA or single-stranded DNA aptamers with 2'-F pyrimidines have been pursued to increase resistance to nucleases, and while it seems likely that these and other modifications, including the modification of...