Tingjian Chen
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Explore the profile of Tingjian Chen including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
481
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Recent Articles
1.
Du Y, Qian C, Li X, Zheng X, Huang S, Yin Z, et al.
Curr Res Food Sci
. 2024 Oct;
9:100867.
PMID: 39376581
Understanding the evolutionary dynamics of foodborne pathogens throughout host-associated habitats is of utmost importance. Bacterial pan-genomes, as dynamic entities, are strongly influenced by ecological lifestyles. As a phenotypically diverse species...
2.
Sun L, Xiang Y, Du Y, Wang Y, Ma J, Wang Y, et al.
Nucleic Acids Res
. 2024 Aug;
52(17):10085-10101.
PMID: 39149896
Xenobiotic nucleic acids (XNAs) are artificial genetic polymers with altered structural moieties and useful features, such as enhanced biological and chemical stability. Enzymatic synthesis and efficient labelling of XNAs are...
3.
Wen C, Wang G, Yang L, Chen T, Liu H, Gong W
J Mol Biol
. 2024 Aug;
436(20):168744.
PMID: 39147125
DNA modified with C2'-methoxy (C2'-OMe) greatly enhances its resistance to nucleases, which is beneficial for the half-life of aptamers and DNA nanomaterials. Although the unnatural DNA polymerases capable of incorporating...
4.
Wang G, Du Y, Chen T
Methods Mol Biol
. 2024 Mar;
2760:133-145.
PMID: 38468086
Efficient preparation of DNA oligonucleotides containing unnatural nucleobases (UBs) that can pair with their cognates to form unnatural base pairs (UBPs) is an essential prerequisite for the application of UBPs...
5.
Cao Y, Bai J, Zou J, Du Y, Chen T
ACS Synth Biol
. 2023 Sep;
12(9):2691-2706.
PMID: 37672623
The genetic alphabet of life has been dramatically expanded via the development of unnatural base pairs (UBPs) that work as efficiently as natural base pairs in the storage and retrieval...
6.
Qin Y, Ma X, Tao R, Du Y, Chen T
ACS Synth Biol
. 2023 Aug;
12(9):2616-2631.
PMID: 37646406
In the past decades, various xenobiotic nucleic acids (XNAs), including 2'-modified nucleic acids, have been developed as novel genetic materials and demonstrated great potential in synthetic biology and biotechnology. Enzymatic...
7.
Bai J, Zou J, Cao Y, Du Y, Chen T
ACS Synth Biol
. 2023 Aug;
12(9):2676-2690.
PMID: 37590442
Unnatural base pairs (UBPs) have been developed to expand the genetic alphabet and . UBP dNaM-dTPT3 and its analogues have been successfully used to construct the first set of semi-synthetic...
8.
Du Y, Zou J, Yin Z, Chen T
Microbiol Spectr
. 2023 Feb;
:e0292422.
PMID: 36853054
Agrobacterium fabrum has been critical for the development of plant genetic engineering and agricultural biotechnology due to its ability to transform eukaryotic cells. However, the gene composition, evolutionary dynamics, and...
9.
Wang G, Du Y, Ma X, Ye F, Qin Y, Wang Y, et al.
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499296
Thermophilic nucleic acid polymerases, isolated from organisms that thrive in extremely hot environments, possess great DNA/RNA synthesis activities under high temperatures. These enzymes play indispensable roles in central life activities...
10.
Wang G, He C, Zou J, Liu J, Du Y, Chen T
ACS Synth Biol
. 2022 Dec;
11(12):4142-4155.
PMID: 36455255
Development of unnatural base pairs (UBPs) has significantly expanded the genetic alphabet both and and led to numerous potential applications in the biotechnology and biopharmaceutical industry. Efficient synthesis of oligonucleotides...