Ting-Chao Chou
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Explore the profile of Ting-Chao Chou including associated specialties, affiliations and a list of published articles.
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78
Citations
5917
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Recent Articles
1.
Lin S, Hsueh C, Chen W, Chou T, Wong R
Cancers (Basel)
. 2025 Feb;
17(3).
PMID: 39941729
Background: Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies and has a poor prognosis. Ataxia telangiectasia mutated and Rad3 related (ATR) is a key regulator for...
2.
Lin S, Lee Y, Wu M, Lu Y, Yeh C, Chen W, et al.
Endocr Relat Cancer
. 2023 Oct;
30(12).
PMID: 37902083
Ataxia telangiectasia and Rad3-related protein (ATR) is a critical component of the DNA damage response and a potential target in the treatment of cancers. An ATR inhibitor, BAY 1895344, was...
3.
Lu Y, Wu M, Lee Y, Chou T, Wong R, Lin S
Cancers (Basel)
. 2021 Jul;
13(14).
PMID: 34298699
Differentiated thyroid cancer (DTC) patients are usually known for their excellent prognoses. However, some patients with DTC develop refractory disease and require novel therapies with different therapeutic mechanisms. Targeting Wee1...
4.
Lu Y, Huang Y, Wu M, Chou T, Wong R, Lin S
Endocr Relat Cancer
. 2021 Mar;
28(5):311-324.
PMID: 33769310
Wee1 is a kinase that regulates the G2/M progression by the inhibition of CDK1, which is critical for ensuring DNA damage repair before initiation of mitotic entry. Targeting Wee1 may...
5.
Lin S, Yeh C, Huang Y, Chou T, Wong R
Cancer Sci
. 2020 Dec;
112(2):803-814.
PMID: 33306266
Polo-like kinases (PLKs) are potent regulators of cell proliferation and cell survival. Polo-like kinases are potential targets in the treatment of anaplastic thyroid cancer (ATC), a rare but deadly disease....
6.
Lin S, Lin J, Yeh C, Huang Y, Chou T, Wong R
Endocr Relat Cancer
. 2019 Jun;
26(8):727-738.
PMID: 31189135
Polo-like kinases (PLKs) are pivotal regulators of cell proliferation and cell survival; therefore, PLKs may be potential targets in the treatment of malignancy. The therapeutic effects of volasertib, a PLKs...
7.
Lin S, Lin J, Hsueh C, Chou T, Wong R
Oncotarget
. 2018 Jul;
9(46):28030-28041.
PMID: 29963260
Altered cyclin-dependent kinase activity is observed in many human malignancies. Cyclin-dependent kinases that promote cell cycle progression may be promising targets in the treatment of cancer. The therapeutic effects of...
8.
Lin S, Lin J, Hsueh C, Chou T, Wong R
Endocr Relat Cancer
. 2018 Jun;
25(10):853-864.
PMID: 29895526
Activation of cyclin-dependent kinase activity is frequently observed in many human cancers; therefore, cyclin-dependent kinases that promote cell cycle transition and cell proliferation may be potential targets in the treatment...
9.
Balog A, Harris C, Savin K, Zhang X, Chou T, Danishefsky S
Angew Chem Int Ed Engl
. 2018 May;
37(19):2675-2678.
PMID: 29711598
The stabilization of the transition state through a favorable interaction between the double bond of 1 and the carbonyl group of 2 appears to be responsible for the high diastereoface...
10.
Lin S, Lin J, Hsueh C, Chou T, Wong R
Oncotarget
. 2017 Oct;
8(40):67990-68000.
PMID: 28978090
Many human cancers have altered cyclin-dependent kinase activity. Inhibition of cyclin-dependent kinases may arrest cell cycle progression and represents an important strategy in the treatment of malignancies. We evaluated the...